MiR-23b and miR-130b expression is downregulated in pituitary adenomas

Vincenza Leone, Concetta Langella, Daniela D'Angelo, Paula Mussnich, Anne Wierinckx, Luigi Terracciano, Gerald Raverot, Joel Lachuer, Sandra Rotondi, Marie Lise Jaffrain-Rea, Jacqueline Trouillas, Alfredo Fusco

Research output: Contribution to journalArticlepeer-review

Abstract

MicroRNA (miRNA) deregulation plays a critical role in tumorigenesis. miR-23b and miR-130b are induced by thyrotropin in thyroid cells in a cAMP-dependent manner.The aim of our work has been to investigate the possible role of miR-23b and miR-130b in pituitary tumorigenesis. We have analyzed their expression in a panel of pituitary adenomas (PAs) including GH and NFPA adenomas.We report that miR-23b and miR-130b are drastically reduced in GH, gonadotroph and NFPA adenomas in comparison with normal pituitary gland. Interestingly, the overexpression of miR-23b and miR-130b inhibits cell proliferation arresting the cells in the G1 and G2 phase of the cell cycle, respectively. Moreover, we demonstrate that miR-23b and miR-130b target HMGA2 and cyclin A2 (CCNA2) genes, respectively. Finally, downregulation of miR-23b and miR-130b expression is associated with increased levels of their respective targets in human PAs.These findings suggest that miR-23b and miR-130b downregulation may contribute to pituitary tumorigenesis.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalMolecular and Cellular Endocrinology
Volume390
Issue number1-2
DOIs
Publication statusPublished - Jun 5 2014

Keywords

  • CCNA2
  • HMGA2
  • MicroRNA
  • Pituitary adenoma

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Biochemistry
  • Medicine(all)

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