MiR-30e∗ is an independent subtype-specific prognostic marker in breast cancer

F. D'Aiuto, M. Callari, M. Dugo, G. Merlino, V. Musella, P. Miodini, B. Paolini, V. Cappelletti, M. G. Daidone

Research output: Contribution to journalArticlepeer-review

Abstract

Background:Breast cancer clinical outcome is affected by tumor molecular features, and the identification of subtype-specific prognostic biomarkers is relevant for breast cancer translational research. Gene expression signatures proved to be able to complement prognostic information provided by classical clinico-pathological features. Recently, microRNAs (miRNAs) have been causally linked to tumorigenesis and cancer progression and have been associated with patient outcome, also in breast cancer.Methods:MicroRNAs associated with the development of distant metastasis were identified in a cohort of 92 ESR1+/ERBB2- lymph node-negative breast cancers from patients not receiving adjuvant treatment. Results were confirmed and further investigated in a total of 1246 miRNA and gene expression profiles of the Molecular Taxonomy of Breast Cancer International Consortium data set. Moderated t-test, univariable and multivariable Cox regression models were used for statistical analyses.Results:miR-30e∗ was identified as independent protective prognostic factor in lymph node-negative untreated patients with ESR1+/ERBB2- tumours and retained a significant association with a good prognosis in treated patients with the same tumor subtype as well as in the ERBB2+ subtype, but not in ESR1-/ERBB2- tumours.Conclusions:We highlighted a relevant and subtype-specific role in breast cancer for miR-30e∗ and demonstrated that adding miRNA markers to gene signatures and clinico-pathological features can help for a better prognostication.

Original languageEnglish
Pages (from-to)290-298
Number of pages9
JournalBritish Journal of Cancer
Volume113
Issue number2
DOIs
Publication statusPublished - Jul 14 2015

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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