miRNA expression profiling divides follicular dendritic cell sarcomas into two groups, related to fibroblasts and myopericytomas or Castleman's disease

Sylvia Hartmann, Claudia Döring, Claudio Agostinelli, Soo Jeong Portscher-Kim, Silvia Lonardi, Luisa Lorenzi, Fabio Fuligni, Daniel Martinez, Jay Mehta, Anita Borges, Holger Hackstein, Stefan Kippenberger, Pier Paolo Piccaluga, Ingrid Simonitsch-Klupp, José Cabeçadas, Elias Campo, Fabio Facchetti, Stefano A. Pileri, Martin Leo Hansmann

Research output: Contribution to journalArticle

Abstract

Follicular dendritic cell (FDC) sarcomas are rare mesenchymal tumours, which are fatal in 20% of the patients and usually occur in secondary lymphoid organs or extranodal localizations. Due to the rareness of these tumours, only few studies have been conducted on molecular level. In the present study, we performed microRNA (miRNA) profiling of 31 FDC sarcomas and identified two subgroups, one with high miRNA expression and the other group with low miRNA expression levels. The first group showed a strong similarity to fibroblasts and myopericytomas, whereas the second group was more closely related to FDCs from Castleman's disease. Both groups showed important differences compared with myeloid-derived dendritic cells, confirming mesenchymal origin of FDCs and their derived sarcomas. The two FDC sarcoma groups did not differ on morphological grounds, mitotic activity or BRAF mutation status. However, patients of group I presented a tendency to a shorter overall survival and more frequent podoplanin expression by immunohistochemistry. The importance of these newly recognized FDC sarcoma subgroups in terms of clinical behaviour and therapeutic implications should be assessed in a larger cohort in future studies.

Original languageEnglish
Pages (from-to)159-166
Number of pages8
JournalEuropean Journal of Cancer
Volume64
DOIs
Publication statusPublished - Sep 1 2016

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Follicular Dendritic Cell Sarcoma
Giant Lymph Node Hyperplasia
MicroRNAs
Fibroblasts
Sarcoma
Dendritic Cells
Neoplasms
Immunohistochemistry
Mutation
Survival

Keywords

  • BRAF
  • Cell of origin
  • Follicular dendritic cell sarcoma
  • Follicular dendritic cells
  • miRNA profiling
  • Podoplanin

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

miRNA expression profiling divides follicular dendritic cell sarcomas into two groups, related to fibroblasts and myopericytomas or Castleman's disease. / Hartmann, Sylvia; Döring, Claudia; Agostinelli, Claudio; Portscher-Kim, Soo Jeong; Lonardi, Silvia; Lorenzi, Luisa; Fuligni, Fabio; Martinez, Daniel; Mehta, Jay; Borges, Anita; Hackstein, Holger; Kippenberger, Stefan; Piccaluga, Pier Paolo; Simonitsch-Klupp, Ingrid; Cabeçadas, José; Campo, Elias; Facchetti, Fabio; Pileri, Stefano A.; Hansmann, Martin Leo.

In: European Journal of Cancer, Vol. 64, 01.09.2016, p. 159-166.

Research output: Contribution to journalArticle

Hartmann, S, Döring, C, Agostinelli, C, Portscher-Kim, SJ, Lonardi, S, Lorenzi, L, Fuligni, F, Martinez, D, Mehta, J, Borges, A, Hackstein, H, Kippenberger, S, Piccaluga, PP, Simonitsch-Klupp, I, Cabeçadas, J, Campo, E, Facchetti, F, Pileri, SA & Hansmann, ML 2016, 'miRNA expression profiling divides follicular dendritic cell sarcomas into two groups, related to fibroblasts and myopericytomas or Castleman's disease', European Journal of Cancer, vol. 64, pp. 159-166. https://doi.org/10.1016/j.ejca.2016.06.004
Hartmann, Sylvia ; Döring, Claudia ; Agostinelli, Claudio ; Portscher-Kim, Soo Jeong ; Lonardi, Silvia ; Lorenzi, Luisa ; Fuligni, Fabio ; Martinez, Daniel ; Mehta, Jay ; Borges, Anita ; Hackstein, Holger ; Kippenberger, Stefan ; Piccaluga, Pier Paolo ; Simonitsch-Klupp, Ingrid ; Cabeçadas, José ; Campo, Elias ; Facchetti, Fabio ; Pileri, Stefano A. ; Hansmann, Martin Leo. / miRNA expression profiling divides follicular dendritic cell sarcomas into two groups, related to fibroblasts and myopericytomas or Castleman's disease. In: European Journal of Cancer. 2016 ; Vol. 64. pp. 159-166.
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abstract = "Follicular dendritic cell (FDC) sarcomas are rare mesenchymal tumours, which are fatal in 20{\%} of the patients and usually occur in secondary lymphoid organs or extranodal localizations. Due to the rareness of these tumours, only few studies have been conducted on molecular level. In the present study, we performed microRNA (miRNA) profiling of 31 FDC sarcomas and identified two subgroups, one with high miRNA expression and the other group with low miRNA expression levels. The first group showed a strong similarity to fibroblasts and myopericytomas, whereas the second group was more closely related to FDCs from Castleman's disease. Both groups showed important differences compared with myeloid-derived dendritic cells, confirming mesenchymal origin of FDCs and their derived sarcomas. The two FDC sarcoma groups did not differ on morphological grounds, mitotic activity or BRAF mutation status. However, patients of group I presented a tendency to a shorter overall survival and more frequent podoplanin expression by immunohistochemistry. The importance of these newly recognized FDC sarcoma subgroups in terms of clinical behaviour and therapeutic implications should be assessed in a larger cohort in future studies.",
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AU - Portscher-Kim, Soo Jeong

AU - Lonardi, Silvia

AU - Lorenzi, Luisa

AU - Fuligni, Fabio

AU - Martinez, Daniel

AU - Mehta, Jay

AU - Borges, Anita

AU - Hackstein, Holger

AU - Kippenberger, Stefan

AU - Piccaluga, Pier Paolo

AU - Simonitsch-Klupp, Ingrid

AU - Cabeçadas, José

AU - Campo, Elias

AU - Facchetti, Fabio

AU - Pileri, Stefano A.

AU - Hansmann, Martin Leo

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