miRNAs in tumor radiation response: bystanders or participants?

Paolo Gandellini, Tiziana Rancati, Riccardo Valdagni, Nadia Zaffaroni

Research output: Contribution to journalArticle

Abstract

There is increasing interest in defining a functional association between miRNAs and tumor radiation response, with the double aim of rationally designing miRNA-based strategies to increase patient radiosensitivity and identifying novel biomarkers of treatment response. Although it has been demonstrated that several miRNAs directly regulate the expression of components of cell pathways relevant to radiosensitivity, and miRNA expression profiles change upon irradiation, understanding the causal role exerted by individual miRNAs in determining tumor radiation response is still at an early stage. Based on available experimental and clinical evidence, we discuss here the potential of miRNAs as targets and/or tools for modulating radioresponsivity at the clinical level, as well as possible predictive biomarkers, underlining present limits and future perspectives.

Original languageEnglish
Pages (from-to)529-539
Number of pages11
JournalTrends in Molecular Medicine
Volume20
Issue number9
DOIs
Publication statusPublished - Sep 1 2014

Fingerprint

MicroRNAs
Radiation
Neoplasms
Radiation Tolerance
Biomarkers
Cellular Structures

Keywords

  • miRNAs
  • prognostic biomarkers
  • radiation response
  • radiotherapy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

miRNAs in tumor radiation response : bystanders or participants? / Gandellini, Paolo; Rancati, Tiziana; Valdagni, Riccardo; Zaffaroni, Nadia.

In: Trends in Molecular Medicine, Vol. 20, No. 9, 01.09.2014, p. 529-539.

Research output: Contribution to journalArticle

@article{9f073551a5e045d9af37e6214fad996b,
title = "miRNAs in tumor radiation response: bystanders or participants?",
abstract = "There is increasing interest in defining a functional association between miRNAs and tumor radiation response, with the double aim of rationally designing miRNA-based strategies to increase patient radiosensitivity and identifying novel biomarkers of treatment response. Although it has been demonstrated that several miRNAs directly regulate the expression of components of cell pathways relevant to radiosensitivity, and miRNA expression profiles change upon irradiation, understanding the causal role exerted by individual miRNAs in determining tumor radiation response is still at an early stage. Based on available experimental and clinical evidence, we discuss here the potential of miRNAs as targets and/or tools for modulating radioresponsivity at the clinical level, as well as possible predictive biomarkers, underlining present limits and future perspectives.",
keywords = "miRNAs, prognostic biomarkers, radiation response, radiotherapy",
author = "Paolo Gandellini and Tiziana Rancati and Riccardo Valdagni and Nadia Zaffaroni",
year = "2014",
month = "9",
day = "1",
doi = "10.1016/j.molmed.2014.07.004",
language = "English",
volume = "20",
pages = "529--539",
journal = "Trends in Molecular Medicine",
issn = "1471-4914",
publisher = "Elsevier Limited",
number = "9",

}

TY - JOUR

T1 - miRNAs in tumor radiation response

T2 - bystanders or participants?

AU - Gandellini, Paolo

AU - Rancati, Tiziana

AU - Valdagni, Riccardo

AU - Zaffaroni, Nadia

PY - 2014/9/1

Y1 - 2014/9/1

N2 - There is increasing interest in defining a functional association between miRNAs and tumor radiation response, with the double aim of rationally designing miRNA-based strategies to increase patient radiosensitivity and identifying novel biomarkers of treatment response. Although it has been demonstrated that several miRNAs directly regulate the expression of components of cell pathways relevant to radiosensitivity, and miRNA expression profiles change upon irradiation, understanding the causal role exerted by individual miRNAs in determining tumor radiation response is still at an early stage. Based on available experimental and clinical evidence, we discuss here the potential of miRNAs as targets and/or tools for modulating radioresponsivity at the clinical level, as well as possible predictive biomarkers, underlining present limits and future perspectives.

AB - There is increasing interest in defining a functional association between miRNAs and tumor radiation response, with the double aim of rationally designing miRNA-based strategies to increase patient radiosensitivity and identifying novel biomarkers of treatment response. Although it has been demonstrated that several miRNAs directly regulate the expression of components of cell pathways relevant to radiosensitivity, and miRNA expression profiles change upon irradiation, understanding the causal role exerted by individual miRNAs in determining tumor radiation response is still at an early stage. Based on available experimental and clinical evidence, we discuss here the potential of miRNAs as targets and/or tools for modulating radioresponsivity at the clinical level, as well as possible predictive biomarkers, underlining present limits and future perspectives.

KW - miRNAs

KW - prognostic biomarkers

KW - radiation response

KW - radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=84931833417&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84931833417&partnerID=8YFLogxK

U2 - 10.1016/j.molmed.2014.07.004

DO - 10.1016/j.molmed.2014.07.004

M3 - Article

C2 - 25153824

VL - 20

SP - 529

EP - 539

JO - Trends in Molecular Medicine

JF - Trends in Molecular Medicine

SN - 1471-4914

IS - 9

ER -