TY - JOUR
T1 - miRNAs in tumor radiation response
T2 - bystanders or participants?
AU - Gandellini, Paolo
AU - Rancati, Tiziana
AU - Valdagni, Riccardo
AU - Zaffaroni, Nadia
PY - 2014/9/1
Y1 - 2014/9/1
N2 - There is increasing interest in defining a functional association between miRNAs and tumor radiation response, with the double aim of rationally designing miRNA-based strategies to increase patient radiosensitivity and identifying novel biomarkers of treatment response. Although it has been demonstrated that several miRNAs directly regulate the expression of components of cell pathways relevant to radiosensitivity, and miRNA expression profiles change upon irradiation, understanding the causal role exerted by individual miRNAs in determining tumor radiation response is still at an early stage. Based on available experimental and clinical evidence, we discuss here the potential of miRNAs as targets and/or tools for modulating radioresponsivity at the clinical level, as well as possible predictive biomarkers, underlining present limits and future perspectives.
AB - There is increasing interest in defining a functional association between miRNAs and tumor radiation response, with the double aim of rationally designing miRNA-based strategies to increase patient radiosensitivity and identifying novel biomarkers of treatment response. Although it has been demonstrated that several miRNAs directly regulate the expression of components of cell pathways relevant to radiosensitivity, and miRNA expression profiles change upon irradiation, understanding the causal role exerted by individual miRNAs in determining tumor radiation response is still at an early stage. Based on available experimental and clinical evidence, we discuss here the potential of miRNAs as targets and/or tools for modulating radioresponsivity at the clinical level, as well as possible predictive biomarkers, underlining present limits and future perspectives.
KW - miRNAs
KW - prognostic biomarkers
KW - radiation response
KW - radiotherapy
UR - http://www.scopus.com/inward/record.url?scp=84931833417&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84931833417&partnerID=8YFLogxK
U2 - 10.1016/j.molmed.2014.07.004
DO - 10.1016/j.molmed.2014.07.004
M3 - Article
C2 - 25153824
VL - 20
SP - 529
EP - 539
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
SN - 1471-4914
IS - 9
ER -