miRNAs, 'stemness' and skin

Daniel Aberdam, Eleonora Candi, Richard A. Knight, Gerry Melino

Research output: Contribution to journalArticlepeer-review

Abstract

The epidermis and its appendages provide organisms with protection from the environment, keeping pathogens out and preventing the loss of essential body fluids. To perform both functions, the skin has elaborated a complex differentiation process known as cornification. The renewal capacity of the skin, which is responsible for maintaining tissue homeostasis, regenerating hair and repairing the epidermis after injury, resides in the basal proliferating compartment in which epidermal stem cells are located. These cells possess the remarkable capacity to both self-perpetuate and give rise to the differentiating cells that form mature tissues. Recent findings indicate that microRNAs have an essential role in orchestrating the formation of epidermis and skin appendages, in particular, at the interface between stemness and differentiation.

Original languageEnglish
Pages (from-to)583-591
Number of pages9
JournalTrends in Biochemical Sciences
Volume33
Issue number12
DOIs
Publication statusPublished - Dec 2008

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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