Mirror image of the amyloid-β species in cerebrospinal fluid and cerebral amyloid in Alzheimer's disease

Marcella Catania, Giuseppe Di Fede, Elisa Tonoli, Luisa Benussi, Claudio Pasquali, Giorgio Giaccone, Emanuela Maderna, Roberta Ghidoni, Fabrizio Tagliavini

Research output: Contribution to journalArticle

Abstract

Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) accumulation in brain that is paralleled by Aβ1-42 reduction in cerebrospinal fluid (CSF). We analyzed the pattern of A peptides, including the N- and C-terminal truncated fragments, in brain and CSF from two familial and one sporadic AD cases. We found that (i) each patient is characterized by a distinct Aβ profile in CSF and brain deposits and (ii) the CSF Aβ pattern mirrors the Aβ profile of cerebral amyloid. These results suggest the existence of different molecular AD subtypes which can be recognized by CSF analysis, enabling patient stratification.

Original languageEnglish
Pages (from-to)877-881
Number of pages5
JournalJournal of Alzheimer's Disease
Volume47
Issue number4
DOIs
Publication statusPublished - Aug 11 2015

Keywords

  • Alzheimer's disease
  • Amyloid-β
  • Biomarker
  • Cerebrospinal fluid
  • SELDI-TOF MS

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

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