Mismatch Negativity Recording in Children with Duchenne Muscular Dystrophy: A Preliminary Study Integrating Neurophysiological and Neuropsychological Results

Melissa Filippini, Angelo Guerra, Alessandra Negosanti, Sara Santi, Jasenka Sarajlija, Muriel Assunta Musti, Giuseppe Gobbi, Maryse Lassonde, Antonella Pini

Research output: Contribution to journalArticle

Abstract

Many studies on Duchenne muscular dystrophy children support the hypothesis of a specific neuropsychological phenotype affecting mostly phonological skills. This prospective study aimed to shed light on the role of phonological abilities. Fourteen Duchenne muscular dystrophy children and 7 healthy children underwent mismatch negativity. Moreover, verbal intelligence, visuospatial attention, immediate verbal memory, working memory, grammar, vocabulary, visuomotor skills, reading, text comprehension, writing, and arithmetic were tested in Duchenne muscular dystrophy children. No significant difference between control and Duchenne muscular dystrophy children was found neither for mismatch negativity amplitude (P =.191 and.116, respectively) nor for latency (P =.135). Eight (57.14%) patients showed an impairment of immediate verbal memory and of visuomotor skills, 7 (63.64%) patients had a deficit in writing and arithmetic skills, even with a mean normal intelligence quotient. Taken together, the results put in evidence a heterogeneous neuropsychological profile not explainable on the basis of a phonological deficit.

Original languageEnglish
Pages (from-to)1468-1474
Number of pages7
JournalJournal of Child Neurology
Volume31
Issue number13
DOIs
Publication statusPublished - Nov 1 2016

Fingerprint

Duchenne Muscular Dystrophy
Short-Term Memory
Intelligence
Aptitude
Vocabulary
Reading
Prospective Studies
Phenotype

Keywords

  • cerebellar hypothesis
  • Duchenne muscular dystrophy
  • mismatch negativity
  • neuropsychological profile
  • phonological hypothesis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Mismatch Negativity Recording in Children with Duchenne Muscular Dystrophy : A Preliminary Study Integrating Neurophysiological and Neuropsychological Results. / Filippini, Melissa; Guerra, Angelo; Negosanti, Alessandra; Santi, Sara; Sarajlija, Jasenka; Musti, Muriel Assunta; Gobbi, Giuseppe; Lassonde, Maryse; Pini, Antonella.

In: Journal of Child Neurology, Vol. 31, No. 13, 01.11.2016, p. 1468-1474.

Research output: Contribution to journalArticle

Filippini, Melissa ; Guerra, Angelo ; Negosanti, Alessandra ; Santi, Sara ; Sarajlija, Jasenka ; Musti, Muriel Assunta ; Gobbi, Giuseppe ; Lassonde, Maryse ; Pini, Antonella. / Mismatch Negativity Recording in Children with Duchenne Muscular Dystrophy : A Preliminary Study Integrating Neurophysiological and Neuropsychological Results. In: Journal of Child Neurology. 2016 ; Vol. 31, No. 13. pp. 1468-1474.
@article{d29ee65e37bf43d28cc8def22b10ec63,
title = "Mismatch Negativity Recording in Children with Duchenne Muscular Dystrophy: A Preliminary Study Integrating Neurophysiological and Neuropsychological Results",
abstract = "Many studies on Duchenne muscular dystrophy children support the hypothesis of a specific neuropsychological phenotype affecting mostly phonological skills. This prospective study aimed to shed light on the role of phonological abilities. Fourteen Duchenne muscular dystrophy children and 7 healthy children underwent mismatch negativity. Moreover, verbal intelligence, visuospatial attention, immediate verbal memory, working memory, grammar, vocabulary, visuomotor skills, reading, text comprehension, writing, and arithmetic were tested in Duchenne muscular dystrophy children. No significant difference between control and Duchenne muscular dystrophy children was found neither for mismatch negativity amplitude (P =.191 and.116, respectively) nor for latency (P =.135). Eight (57.14{\%}) patients showed an impairment of immediate verbal memory and of visuomotor skills, 7 (63.64{\%}) patients had a deficit in writing and arithmetic skills, even with a mean normal intelligence quotient. Taken together, the results put in evidence a heterogeneous neuropsychological profile not explainable on the basis of a phonological deficit.",
keywords = "cerebellar hypothesis, Duchenne muscular dystrophy, mismatch negativity, neuropsychological profile, phonological hypothesis",
author = "Melissa Filippini and Angelo Guerra and Alessandra Negosanti and Sara Santi and Jasenka Sarajlija and Musti, {Muriel Assunta} and Giuseppe Gobbi and Maryse Lassonde and Antonella Pini",
year = "2016",
month = "11",
day = "1",
doi = "10.1177/0883073816656404",
language = "English",
volume = "31",
pages = "1468--1474",
journal = "Journal of Child Neurology",
issn = "0883-0738",
publisher = "SAGE Publications Inc.",
number = "13",

}

TY - JOUR

T1 - Mismatch Negativity Recording in Children with Duchenne Muscular Dystrophy

T2 - A Preliminary Study Integrating Neurophysiological and Neuropsychological Results

AU - Filippini, Melissa

AU - Guerra, Angelo

AU - Negosanti, Alessandra

AU - Santi, Sara

AU - Sarajlija, Jasenka

AU - Musti, Muriel Assunta

AU - Gobbi, Giuseppe

AU - Lassonde, Maryse

AU - Pini, Antonella

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Many studies on Duchenne muscular dystrophy children support the hypothesis of a specific neuropsychological phenotype affecting mostly phonological skills. This prospective study aimed to shed light on the role of phonological abilities. Fourteen Duchenne muscular dystrophy children and 7 healthy children underwent mismatch negativity. Moreover, verbal intelligence, visuospatial attention, immediate verbal memory, working memory, grammar, vocabulary, visuomotor skills, reading, text comprehension, writing, and arithmetic were tested in Duchenne muscular dystrophy children. No significant difference between control and Duchenne muscular dystrophy children was found neither for mismatch negativity amplitude (P =.191 and.116, respectively) nor for latency (P =.135). Eight (57.14%) patients showed an impairment of immediate verbal memory and of visuomotor skills, 7 (63.64%) patients had a deficit in writing and arithmetic skills, even with a mean normal intelligence quotient. Taken together, the results put in evidence a heterogeneous neuropsychological profile not explainable on the basis of a phonological deficit.

AB - Many studies on Duchenne muscular dystrophy children support the hypothesis of a specific neuropsychological phenotype affecting mostly phonological skills. This prospective study aimed to shed light on the role of phonological abilities. Fourteen Duchenne muscular dystrophy children and 7 healthy children underwent mismatch negativity. Moreover, verbal intelligence, visuospatial attention, immediate verbal memory, working memory, grammar, vocabulary, visuomotor skills, reading, text comprehension, writing, and arithmetic were tested in Duchenne muscular dystrophy children. No significant difference between control and Duchenne muscular dystrophy children was found neither for mismatch negativity amplitude (P =.191 and.116, respectively) nor for latency (P =.135). Eight (57.14%) patients showed an impairment of immediate verbal memory and of visuomotor skills, 7 (63.64%) patients had a deficit in writing and arithmetic skills, even with a mean normal intelligence quotient. Taken together, the results put in evidence a heterogeneous neuropsychological profile not explainable on the basis of a phonological deficit.

KW - cerebellar hypothesis

KW - Duchenne muscular dystrophy

KW - mismatch negativity

KW - neuropsychological profile

KW - phonological hypothesis

UR - http://www.scopus.com/inward/record.url?scp=84991230468&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84991230468&partnerID=8YFLogxK

U2 - 10.1177/0883073816656404

DO - 10.1177/0883073816656404

M3 - Article

C2 - 27422795

AN - SCOPUS:84991230468

VL - 31

SP - 1468

EP - 1474

JO - Journal of Child Neurology

JF - Journal of Child Neurology

SN - 0883-0738

IS - 13

ER -