Mismatch responses evoked by nociceptive stimuli

Li Hu, Chen Zhao, Hong Li, Elia Valentini

Research output: Contribution to journalArticlepeer-review


We studied whether nociceptive mismatch negativity (nMMN) could be obtained as result of nociceptive fibers stimulation. The purported nMMN revealed a topography similar to the somatosensory MMN (sMMN), which was observed at the bilateral temporal regions of the scalp. Importantly, only early negativities (100-250ms) located at these regions revealed a selective modulation associated to the processing of deviancy regardless of the attentional focus. The amplitude modulation of the sMMN had an earlier onset than the nMMN (110ms vs. 182ms) as well as a larger difference of latency between the contralateral and the ipsilateral onset of the activity (52ms vs. 4ms). Altogether, these observations provide evidence that (a) a nMMN can be elicited by nociceptive stimuli, and (b) the nMMN is topographically similar to the sMMN while differing in latency and possibly in functional organization of their generators.

Original languageEnglish
Pages (from-to)158-173
Number of pages16
Issue number2
Publication statusPublished - Feb 2013


  • Attention
  • Electroencephalography
  • Mismatch negativity
  • Nociceptive system
  • Somatosensory system

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Experimental and Cognitive Psychology
  • Neuropsychology and Physiological Psychology
  • Arts and Humanities (miscellaneous)
  • Developmental and Educational Psychology

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