Misoprostol and congenital anomalies

Rita Brasil; Helena Lutscia Coelho; Barbara D&apos;Avanzo; Carlo La Vecchia

doi:10.1002/1099-1557(200009/10)9:5<401::AID-PDS527>3.0.CO;2-1

Misoprostol and congenital anomalies

Rita Brasil, Helena Lutscia Coelho, Barbara D'Avanzo, Carlo La Vecchia

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose - To evaluate the risk of having a baby with congenital anomalies in mothers who used misoprostol during pregnancy. Methods - Hospital-based case-control study from Hospital Chateaubriand, Fortaleza, Brasil. Cases were 37 babies weighing less than 1500 g with congenital anomalies of various types, and the comparison group included 387 infants also weighing less than 1500 g, and without congenital anomalies. Results - The multivariate odds ratio of having a baby with congenital anomalies was 2.4 (95% confidence interval 1.0-6.2) in mothers who reported having used misoprostol compared with those who did not. Conclusions - Misoprostol use during pregnancy might be related to a broad spectrum of congenital anomalies in infants. Copyright (C) 2000 John Wiley and Sons, Ltd.

Original language	English
Pages (from-to)	401-403
Number of pages	3
Journal	Pharmacoepidemiology and Drug Safety
Volume	9
Issue number	5
DOIs	https://doi.org/10.1002/1099-1557(200009/10)9:5<401::AID-PDS527>3.0.CO;2-1
Publication status	Published - 2000

Keywords

Congenital anomalies
Induced abortions
Low birth weight
Misoprostol
Risk

ASJC Scopus subject areas

Pharmacology (medical)
Pharmacology, Toxicology and Pharmaceutics(all)

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title = "Misoprostol and congenital anomalies",

abstract = "Purpose - To evaluate the risk of having a baby with congenital anomalies in mothers who used misoprostol during pregnancy. Methods - Hospital-based case-control study from Hospital Chateaubriand, Fortaleza, Brasil. Cases were 37 babies weighing less than 1500 g with congenital anomalies of various types, and the comparison group included 387 infants also weighing less than 1500 g, and without congenital anomalies. Results - The multivariate odds ratio of having a baby with congenital anomalies was 2.4 (95% confidence interval 1.0-6.2) in mothers who reported having used misoprostol compared with those who did not. Conclusions - Misoprostol use during pregnancy might be related to a broad spectrum of congenital anomalies in infants. Copyright (C) 2000 John Wiley and Sons, Ltd.",

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author = "Rita Brasil and Coelho, {Helena Lutscia} and Barbara D'Avanzo and {La Vecchia}, Carlo",

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doi = "10.1002/1099-1557(200009/10)9:5<401::AID-PDS527>3.0.CO;2-1",

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AU - Brasil, Rita

AU - Coelho, Helena Lutscia

AU - D'Avanzo, Barbara

AU - La Vecchia, Carlo

PY - 2000

Y1 - 2000

N2 - Purpose - To evaluate the risk of having a baby with congenital anomalies in mothers who used misoprostol during pregnancy. Methods - Hospital-based case-control study from Hospital Chateaubriand, Fortaleza, Brasil. Cases were 37 babies weighing less than 1500 g with congenital anomalies of various types, and the comparison group included 387 infants also weighing less than 1500 g, and without congenital anomalies. Results - The multivariate odds ratio of having a baby with congenital anomalies was 2.4 (95% confidence interval 1.0-6.2) in mothers who reported having used misoprostol compared with those who did not. Conclusions - Misoprostol use during pregnancy might be related to a broad spectrum of congenital anomalies in infants. Copyright (C) 2000 John Wiley and Sons, Ltd.

AB - Purpose - To evaluate the risk of having a baby with congenital anomalies in mothers who used misoprostol during pregnancy. Methods - Hospital-based case-control study from Hospital Chateaubriand, Fortaleza, Brasil. Cases were 37 babies weighing less than 1500 g with congenital anomalies of various types, and the comparison group included 387 infants also weighing less than 1500 g, and without congenital anomalies. Results - The multivariate odds ratio of having a baby with congenital anomalies was 2.4 (95% confidence interval 1.0-6.2) in mothers who reported having used misoprostol compared with those who did not. Conclusions - Misoprostol use during pregnancy might be related to a broad spectrum of congenital anomalies in infants. Copyright (C) 2000 John Wiley and Sons, Ltd.

KW - Congenital anomalies

KW - Induced abortions

KW - Low birth weight

KW - Misoprostol

KW - Risk

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Misoprostol and congenital anomalies

Abstract

Keywords

ASJC Scopus subject areas

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