Misoprostol and congenital anomalies

Rita Brasil, Helena Lutscia Coelho, Barbara D'Avanzo, Carlo La Vecchia

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose - To evaluate the risk of having a baby with congenital anomalies in mothers who used misoprostol during pregnancy. Methods - Hospital-based case-control study from Hospital Chateaubriand, Fortaleza, Brasil. Cases were 37 babies weighing less than 1500 g with congenital anomalies of various types, and the comparison group included 387 infants also weighing less than 1500 g, and without congenital anomalies. Results - The multivariate odds ratio of having a baby with congenital anomalies was 2.4 (95% confidence interval 1.0-6.2) in mothers who reported having used misoprostol compared with those who did not. Conclusions - Misoprostol use during pregnancy might be related to a broad spectrum of congenital anomalies in infants. Copyright (C) 2000 John Wiley and Sons, Ltd.

Original languageEnglish
Pages (from-to)401-403
Number of pages3
JournalPharmacoepidemiology and Drug Safety
Volume9
Issue number5
DOIs
Publication statusPublished - 2000

Keywords

  • Congenital anomalies
  • Induced abortions
  • Low birth weight
  • Misoprostol
  • Risk

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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