Missed opportunities to prevent mother-to-child transmission of HIV in Italy

The Italian Register for HIV Infection in Children, A. Di Biagio, L. Taramasso, G. Gustinetti, G. Burastero, V. Giacomet, D. La Rovere, O. Genovese, C. Giaquinto, O. Rampon, I. Carloni, T. K. Hyppolite, L. Palandri, S. Bernardi, E. Bruzzese, R. Badolato, C. Gabiano, E. Chiappini, M. De Martino, L. Galli & 31 others Patrizia Osimani, Domenico Larovere, Maurizio Ruggeri, Andrea Pession, Giacomo Faldella, Francesca Capra, Sara Pulcini, Valentina Zattoni, Laura Dotta, Antonia Aliffi, Elisa Anastasio, Elisa Fiumana, Paola Gervaso, Carlotta Montagnani, Claudio Viscoli, Paola Erba, Gian Vincenzo Zuccotti, Annarita Benincaso, Filippo Salvini, Rita Lipreri, Susanna Esposito, Anna Plebani, Claudia Tagliabue, Francesca Giubbarelli, Emanuele Nicastro, Andrea Lo Vecchio, C. Giaquinto, Domenico Zanaboni, Paolo Palma, Giuseppe Pontrelli, Hyppolite Tchidjou

Research output: Contribution to journalArticle

Abstract

Objectives: Vertical transmission of HIV can be effectively controlled through antenatal screening, antiretroviral treatment and the services provided during and after childbirth for mother and newborn. In Italy, the National Health Service guarantees universal access to prenatal care for all women, including women with HIV infection. Despite this, children are diagnosed with HIV infection every year. The aim of the study was to identify missed opportunities for prevention of mother-to-child transmission of HIV. Methods: The Italian Register for HIV Infection in Children, which was started in 1985 and involves 106 hospitals throughout the country, collects data on all new cases of HIV infection in children. For this analysis, we reviewed the database for the period 2005 to 2015. Results: We found 79 HIV-1-infected children newly diagnosed after birth in Italy. Thirty-two of the mothers were Italian. During the pregnancy, only 15 of 19 women with a known HIV diagnosis were treated with antiretroviral treatment, while, of 34 women who had received an HIV diagnosis before labour began, only 23 delivered by caesarean section and 17 received intrapartum prophylaxis. In 25 mothers, HIV infection was diagnosed during pregnancy or in the peripartum period. Thirty-one newborns received antiretroviral prophylaxis and 39 received infant formula. Conclusions: We found an unacceptable number of missed opportunities to prevent mother-to-child transmission (MCTC). Eliminating HIV MTCT is a universal World Health Organization goal. Elucidating organization failures in Italy over the past decade should help to improve early diagnosis and to reach the zero transmission target in newborns.
Original languageEnglish
Pages (from-to)330-336
Number of pages7
JournalHIV Medicine
Volume20
Issue number5
DOIs
Publication statusPublished - May 1 2019

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Italy
HIV Infections
Mothers
HIV
Newborn Infant
Parturition
Peripartum Period
Pregnancy
Infant Formula
Prenatal Care
National Health Programs
Prenatal Diagnosis
Cesarean Section
HIV-1
Early Diagnosis
Organizations
Databases
Therapeutics

Keywords

  • children
  • HIV
  • missed opportunities
  • mothers
  • newborns
  • pregnancy

Cite this

Children, T. I. R. F. HIV. I. I., Di Biagio, A., Taramasso, L., Gustinetti, G., Burastero, G., Giacomet, V., ... Tchidjou, H. (2019). Missed opportunities to prevent mother-to-child transmission of HIV in Italy. HIV Medicine, 20(5), 330-336. https://doi.org/10.1111/hiv.12728

Missed opportunities to prevent mother-to-child transmission of HIV in Italy. / Children, The Italian Register for HIV Infection in; Di Biagio, A.; Taramasso, L.; Gustinetti, G.; Burastero, G.; Giacomet, V.; La Rovere, D.; Genovese, O.; Giaquinto, C.; Rampon, O.; Carloni, I.; Hyppolite, T. K.; Palandri, L.; Bernardi, S.; Bruzzese, E.; Badolato, R.; Gabiano, C.; Chiappini, E.; De Martino, M.; Galli, L.; Osimani, Patrizia; Larovere, Domenico; Ruggeri, Maurizio; Pession, Andrea; Faldella, Giacomo; Capra, Francesca; Pulcini, Sara; Zattoni, Valentina; Dotta, Laura; Aliffi, Antonia; Anastasio, Elisa; Fiumana, Elisa; Gervaso, Paola; Montagnani, Carlotta; Viscoli, Claudio; Erba, Paola; Zuccotti, Gian Vincenzo; Benincaso, Annarita; Salvini, Filippo; Lipreri, Rita; Esposito, Susanna; Plebani, Anna; Tagliabue, Claudia; Giubbarelli, Francesca; Nicastro, Emanuele; Lo Vecchio, Andrea; Giaquinto, C.; Zanaboni, Domenico; Palma, Paolo; Pontrelli, Giuseppe; Tchidjou, Hyppolite.

In: HIV Medicine, Vol. 20, No. 5, 01.05.2019, p. 330-336.

Research output: Contribution to journalArticle

Children, TIRFHIVII, Di Biagio, A, Taramasso, L, Gustinetti, G, Burastero, G, Giacomet, V, La Rovere, D, Genovese, O, Giaquinto, C, Rampon, O, Carloni, I, Hyppolite, TK, Palandri, L, Bernardi, S, Bruzzese, E, Badolato, R, Gabiano, C, Chiappini, E, De Martino, M, Galli, L, Osimani, P, Larovere, D, Ruggeri, M, Pession, A, Faldella, G, Capra, F, Pulcini, S, Zattoni, V, Dotta, L, Aliffi, A, Anastasio, E, Fiumana, E, Gervaso, P, Montagnani, C, Viscoli, C, Erba, P, Zuccotti, GV, Benincaso, A, Salvini, F, Lipreri, R, Esposito, S, Plebani, A, Tagliabue, C, Giubbarelli, F, Nicastro, E, Lo Vecchio, A, Giaquinto, C, Zanaboni, D, Palma, P, Pontrelli, G & Tchidjou, H 2019, 'Missed opportunities to prevent mother-to-child transmission of HIV in Italy', HIV Medicine, vol. 20, no. 5, pp. 330-336. https://doi.org/10.1111/hiv.12728
Children TIRFHIVII, Di Biagio A, Taramasso L, Gustinetti G, Burastero G, Giacomet V et al. Missed opportunities to prevent mother-to-child transmission of HIV in Italy. HIV Medicine. 2019 May 1;20(5):330-336. https://doi.org/10.1111/hiv.12728
Children, The Italian Register for HIV Infection in ; Di Biagio, A. ; Taramasso, L. ; Gustinetti, G. ; Burastero, G. ; Giacomet, V. ; La Rovere, D. ; Genovese, O. ; Giaquinto, C. ; Rampon, O. ; Carloni, I. ; Hyppolite, T. K. ; Palandri, L. ; Bernardi, S. ; Bruzzese, E. ; Badolato, R. ; Gabiano, C. ; Chiappini, E. ; De Martino, M. ; Galli, L. ; Osimani, Patrizia ; Larovere, Domenico ; Ruggeri, Maurizio ; Pession, Andrea ; Faldella, Giacomo ; Capra, Francesca ; Pulcini, Sara ; Zattoni, Valentina ; Dotta, Laura ; Aliffi, Antonia ; Anastasio, Elisa ; Fiumana, Elisa ; Gervaso, Paola ; Montagnani, Carlotta ; Viscoli, Claudio ; Erba, Paola ; Zuccotti, Gian Vincenzo ; Benincaso, Annarita ; Salvini, Filippo ; Lipreri, Rita ; Esposito, Susanna ; Plebani, Anna ; Tagliabue, Claudia ; Giubbarelli, Francesca ; Nicastro, Emanuele ; Lo Vecchio, Andrea ; Giaquinto, C. ; Zanaboni, Domenico ; Palma, Paolo ; Pontrelli, Giuseppe ; Tchidjou, Hyppolite. / Missed opportunities to prevent mother-to-child transmission of HIV in Italy. In: HIV Medicine. 2019 ; Vol. 20, No. 5. pp. 330-336.
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abstract = "Objectives: Vertical transmission of HIV can be effectively controlled through antenatal screening, antiretroviral treatment and the services provided during and after childbirth for mother and newborn. In Italy, the National Health Service guarantees universal access to prenatal care for all women, including women with HIV infection. Despite this, children are diagnosed with HIV infection every year. The aim of the study was to identify missed opportunities for prevention of mother-to-child transmission of HIV. Methods: The Italian Register for HIV Infection in Children, which was started in 1985 and involves 106 hospitals throughout the country, collects data on all new cases of HIV infection in children. For this analysis, we reviewed the database for the period 2005 to 2015. Results: We found 79 HIV-1-infected children newly diagnosed after birth in Italy. Thirty-two of the mothers were Italian. During the pregnancy, only 15 of 19 women with a known HIV diagnosis were treated with antiretroviral treatment, while, of 34 women who had received an HIV diagnosis before labour began, only 23 delivered by caesarean section and 17 received intrapartum prophylaxis. In 25 mothers, HIV infection was diagnosed during pregnancy or in the peripartum period. Thirty-one newborns received antiretroviral prophylaxis and 39 received infant formula. Conclusions: We found an unacceptable number of missed opportunities to prevent mother-to-child transmission (MCTC). Eliminating HIV MTCT is a universal World Health Organization goal. Elucidating organization failures in Italy over the past decade should help to improve early diagnosis and to reach the zero transmission target in newborns.",
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author = "Children, {The Italian Register for HIV Infection in} and {Di Biagio}, A. and L. Taramasso and G. Gustinetti and G. Burastero and V. Giacomet and {La Rovere}, D. and O. Genovese and C. Giaquinto and O. Rampon and I. Carloni and Hyppolite, {T. K.} and L. Palandri and S. Bernardi and E. Bruzzese and R. Badolato and C. Gabiano and E. Chiappini and {De Martino}, M. and L. Galli and Patrizia Osimani and Domenico Larovere and Maurizio Ruggeri and Andrea Pession and Giacomo Faldella and Francesca Capra and Sara Pulcini and Valentina Zattoni and Laura Dotta and Antonia Aliffi and Elisa Anastasio and Elisa Fiumana and Paola Gervaso and Carlotta Montagnani and Claudio Viscoli and Paola Erba and Zuccotti, {Gian Vincenzo} and Annarita Benincaso and Filippo Salvini and Rita Lipreri and Susanna Esposito and Anna Plebani and Claudia Tagliabue and Francesca Giubbarelli and Emanuele Nicastro and {Lo Vecchio}, Andrea and C. Giaquinto and Domenico Zanaboni and Paolo Palma and Giuseppe Pontrelli and Hyppolite Tchidjou",
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T1 - Missed opportunities to prevent mother-to-child transmission of HIV in Italy

AU - Children, The Italian Register for HIV Infection in

AU - Di Biagio, A.

AU - Taramasso, L.

AU - Gustinetti, G.

AU - Burastero, G.

AU - Giacomet, V.

AU - La Rovere, D.

AU - Genovese, O.

AU - Giaquinto, C.

AU - Rampon, O.

AU - Carloni, I.

AU - Hyppolite, T. K.

AU - Palandri, L.

AU - Bernardi, S.

AU - Bruzzese, E.

AU - Badolato, R.

AU - Gabiano, C.

AU - Chiappini, E.

AU - De Martino, M.

AU - Galli, L.

AU - Osimani, Patrizia

AU - Larovere, Domenico

AU - Ruggeri, Maurizio

AU - Pession, Andrea

AU - Faldella, Giacomo

AU - Capra, Francesca

AU - Pulcini, Sara

AU - Zattoni, Valentina

AU - Dotta, Laura

AU - Aliffi, Antonia

AU - Anastasio, Elisa

AU - Fiumana, Elisa

AU - Gervaso, Paola

AU - Montagnani, Carlotta

AU - Viscoli, Claudio

AU - Erba, Paola

AU - Zuccotti, Gian Vincenzo

AU - Benincaso, Annarita

AU - Salvini, Filippo

AU - Lipreri, Rita

AU - Esposito, Susanna

AU - Plebani, Anna

AU - Tagliabue, Claudia

AU - Giubbarelli, Francesca

AU - Nicastro, Emanuele

AU - Lo Vecchio, Andrea

AU - Giaquinto, C.

AU - Zanaboni, Domenico

AU - Palma, Paolo

AU - Pontrelli, Giuseppe

AU - Tchidjou, Hyppolite

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Objectives: Vertical transmission of HIV can be effectively controlled through antenatal screening, antiretroviral treatment and the services provided during and after childbirth for mother and newborn. In Italy, the National Health Service guarantees universal access to prenatal care for all women, including women with HIV infection. Despite this, children are diagnosed with HIV infection every year. The aim of the study was to identify missed opportunities for prevention of mother-to-child transmission of HIV. Methods: The Italian Register for HIV Infection in Children, which was started in 1985 and involves 106 hospitals throughout the country, collects data on all new cases of HIV infection in children. For this analysis, we reviewed the database for the period 2005 to 2015. Results: We found 79 HIV-1-infected children newly diagnosed after birth in Italy. Thirty-two of the mothers were Italian. During the pregnancy, only 15 of 19 women with a known HIV diagnosis were treated with antiretroviral treatment, while, of 34 women who had received an HIV diagnosis before labour began, only 23 delivered by caesarean section and 17 received intrapartum prophylaxis. In 25 mothers, HIV infection was diagnosed during pregnancy or in the peripartum period. Thirty-one newborns received antiretroviral prophylaxis and 39 received infant formula. Conclusions: We found an unacceptable number of missed opportunities to prevent mother-to-child transmission (MCTC). Eliminating HIV MTCT is a universal World Health Organization goal. Elucidating organization failures in Italy over the past decade should help to improve early diagnosis and to reach the zero transmission target in newborns.

AB - Objectives: Vertical transmission of HIV can be effectively controlled through antenatal screening, antiretroviral treatment and the services provided during and after childbirth for mother and newborn. In Italy, the National Health Service guarantees universal access to prenatal care for all women, including women with HIV infection. Despite this, children are diagnosed with HIV infection every year. The aim of the study was to identify missed opportunities for prevention of mother-to-child transmission of HIV. Methods: The Italian Register for HIV Infection in Children, which was started in 1985 and involves 106 hospitals throughout the country, collects data on all new cases of HIV infection in children. For this analysis, we reviewed the database for the period 2005 to 2015. Results: We found 79 HIV-1-infected children newly diagnosed after birth in Italy. Thirty-two of the mothers were Italian. During the pregnancy, only 15 of 19 women with a known HIV diagnosis were treated with antiretroviral treatment, while, of 34 women who had received an HIV diagnosis before labour began, only 23 delivered by caesarean section and 17 received intrapartum prophylaxis. In 25 mothers, HIV infection was diagnosed during pregnancy or in the peripartum period. Thirty-one newborns received antiretroviral prophylaxis and 39 received infant formula. Conclusions: We found an unacceptable number of missed opportunities to prevent mother-to-child transmission (MCTC). Eliminating HIV MTCT is a universal World Health Organization goal. Elucidating organization failures in Italy over the past decade should help to improve early diagnosis and to reach the zero transmission target in newborns.

KW - children

KW - HIV

KW - missed opportunities

KW - mothers

KW - newborns

KW - pregnancy

U2 - 10.1111/hiv.12728

DO - 10.1111/hiv.12728

M3 - Article

VL - 20

SP - 330

EP - 336

JO - HIV Medicine

JF - HIV Medicine

SN - 1464-2662

IS - 5

ER -