Missed treatment in an Italian HBV infected patients cohort: HBV RER

Gianluca Cuomo, Vanni Borghi, Pietro Andreone, Marco Massari, Erica Villa, Antonello Pietrangelo, Gabriella Verucchi, Carlo Ferrari, C. Ferrari, T. Giuberti, E. Villa, P. Andreone, A. Pietrangelo, G. Abbati, G. Magnani, M. Massari, G. Verucchi, C. Cancellieri, S. Ricca Rosellini, F. LevantesiG. Mazzella, D. Sacchini, G. Fornaciari, C. Mussini, V. Borghi, F. Foschi, M. Libanore, S. D. Carradori, C. Contini, G. Ballardini, S. Macchia, S. Boccia, C. Vandelli, P. Bassi, M. Zanotti, P. Loria, G. Sbolli, F. Fornari, P. V. di Maira, S. Bellentani, M. Arlotti, C. Grosso, G. Bolondi, P. Pazzi, A. Mazzocchi, A. Govoni, P. Fusaroli, P. L. Giacomoni, M. Lenzi, G. Pedretti, HBV-RER Group

Research output: Contribution to journalArticle


Background and aims Very little is known about the access to treatment for Chronic Hepatitis B in the real clinical practice and the characteristics of the patients who do not receive antiviral therapy. Methods HBV-RER is an observational multicenter network that collected data of patients with HBV infection during a 3 years observational period (2009–2012). Results Among 2527 HBsAg positive patients, 1099 were never treated (NT); only 280 were included in the analysis due to different exclusion causes A minority was HBeAg-positive. The median age was 42. At liver biopsy most patients had Metavir score of F0-F1. Univariate analysis between 280 NT patients and the 290 naïve to treatment showed that NT patients were mostly female (P = 0.002), not Italian (P = 0.044), younger (P < 0.001). Metavir score was lower in NT (P0.002), such as the Fib4 score (P < 0.001). HBV DNA level was significantly higher in NT. At multivariate analysis, independent variables associated with no-treatment were younger age, female gender, Metavir score F0-F1, Fib4 lower than 1.6 and lower blood level of HBV-DNA. Conclusions There is a large number of patients eligible to treatment who do not receive it. A younger age and a less severe disease seem to be associated to deferral of treatment.

Original languageEnglish
Pages (from-to)1346-1350
Number of pages5
JournalDigestive and Liver Disease
Issue number11
Publication statusPublished - Nov 1 2016



  • HBV
  • Hepatitis B treatment
  • Liver fibrosis

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Cuomo, G., Borghi, V., Andreone, P., Massari, M., Villa, E., Pietrangelo, A., Verucchi, G., Ferrari, C., Ferrari, C., Giuberti, T., Villa, E., Andreone, P., Pietrangelo, A., Abbati, G., Magnani, G., Massari, M., Verucchi, G., Cancellieri, C., Ricca Rosellini, S., ... HBV-RER Group (2016). Missed treatment in an Italian HBV infected patients cohort: HBV RER. Digestive and Liver Disease, 48(11), 1346-1350. https://doi.org/10.1016/j.dld.2016.07.016