"Misura" project: A retrospective survey on the use of 5fluorouracil in the treatment of colorectal cancer in 24 Italian clinical centers

Paola Poletti, Graziella Pinotti, Gerardo Rosati, Gabriele Luppi, Toni Ibrahim, Claudio Marinozzi, Francesca Pucci, Gianfranco Pancera, Guido Biasco, Sandro Barni, Carlo Garufi, Giancarlo Martignoni, Giovanni Visonà, Roberto Labianca

Research output: Contribution to journalArticlepeer-review

Abstract

The "Misura" project is a retrospective survey, with the aim to evaluate how 5FU is used in the treatment of colorectal cancer in clinical practice in Italian oncology departments. Twenty-four centers participated. Patients seen in the second half of 1998 with colorectal cancer and treated with 5FU were analyzed. Observed patients were 664, 45.9% of patients presented metastatic disease. Biochemical modulation with folinic acid and bolus 5FU was the most used schedule (59%). The De Gramont (LV 5FU2) regimen, alone or with other cytotoxic drugs, was the second most chosen schedule (14%). The most frequent side effect observed was gastrointestinal toxicity. No hematological toxicity was demonstrated in 68.8% of patients. Cutaneous toxicity occurred in 21.1% of patients. 5FU is widely used independently by the stage of disease. In palliative treatment a variety of schedules were administered by the Italian centers, lacking a standard therapy. There are very few surveys investigating oncology clinical practice. A larger survey on this issue is auspicable.

Original languageEnglish
Pages (from-to)104-109
Number of pages6
JournalTumori
Volume88
Issue number2
Publication statusPublished - 2002

Keywords

  • 5Fluorouracil
  • Clinical practice
  • Colorectal cancer

ASJC Scopus subject areas

  • Cancer Research

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