Mitii™ ABI: Study protocol of a randomised controlled trial of a web-based multi-modal training program for children and adolescents with an Acquired Brain Injury (ABI)

Roslyn N. Boyd, Emmah Baque, Adina Piovesana, Stephanie Ross, Jenny Ziviani, Leanne Sakzewski, Lee Barber, Owen Lloyd, Lynne McKinlay, Koa Whittingham, Anthony C. Smith, Stephen Rose, Simona Fiori, Ross Cunnington, Robert Ware, Melinda Lewis, Tracy A. Comans, Paul A. Scuffham

Research output: Contribution to journalArticle

Abstract

Background: Acquired brain injury (ABI) refers to multiple disabilities arising from damage to the brain acquired after birth. Children with an ABI may experience physical, cognitive, social and emotional-behavioural impairments which can impact their ability to participate in activities of daily living (ADL). Recent developments in technology have led to the emergence of internet-delivered therapy programs. "Move it to improve it" (Mitii™) is a web-based multi-modal therapy that comprises upper limb (UL) and cognitive training within the context of meaningful physical activity. The proposed study aims to compare the efficacy of Mitii™ to usual care to improve ADL motor and processing skills, gross motor capacity, UL and executive functioning in a randomised waitlist controlled trial. Methods/Design: Sixty independently ambulant children (30 in each group) at least 12 months post ABI will be recruited to participate in this trial. Children will be matched in pairs at baseline and randomly allocated to receive either 20 weeks of Mitii™ training (30 min per day, six days a week, with a potential total dose of 60 h) immediately, or be waitlisted for 20 weeks. Outcomes will be assessed at baseline, immediately post-intervention and at 20 weeks post-intervention. The primary outcomes will be the Assessment of Motor and Process Skills and 30 s repetition maximum of functional strength exercises (sit-to-stand, step-ups and half kneel to stand). Measures of body structure and functions, activity, participation and quality of life will assess the efficacy of Mitii™ across all domains of the International Classification of Functioning, Disability and Health framework. A subset of children will undertake three tesla (3T) magnetic resonance imaging scans to evaluate functional neurovascular changes, structural imaging, diffusion imaging and resting state functional connectivity before and after intervention. Discussion: Mitii™ provides an alternative approach to deliver intensive therapy for children with an ABI in the convenience of the home environment. If Mitii™ is found to be effective, it may offer an accessible and inexpensive intervention option to increase therapy dose. Trial Registration:ANZCTR12613000403730

Original languageEnglish
Article number140
JournalBMC Neurology
Volume15
Issue number1
DOIs
Publication statusPublished - Aug 19 2015

Fingerprint

Brain Injuries
Randomized Controlled Trials
Education
Motor Skills
Activities of Daily Living
Upper Extremity
Exercise
International Classification of Functioning, Disability and Health
Body Weights and Measures
Aptitude
Process Assessment (Health Care)
Therapeutics
Internet
Quality of Life
Magnetic Resonance Imaging
Parturition
Technology
Brain

Keywords

  • Acquired Brain Injury
  • Children
  • Executive Function
  • Motor Processing
  • Physical Activity
  • Protocol
  • Randomised Controlled Trial
  • Virtual Reality

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Mitii™ ABI : Study protocol of a randomised controlled trial of a web-based multi-modal training program for children and adolescents with an Acquired Brain Injury (ABI). / Boyd, Roslyn N.; Baque, Emmah; Piovesana, Adina; Ross, Stephanie; Ziviani, Jenny; Sakzewski, Leanne; Barber, Lee; Lloyd, Owen; McKinlay, Lynne; Whittingham, Koa; Smith, Anthony C.; Rose, Stephen; Fiori, Simona; Cunnington, Ross; Ware, Robert; Lewis, Melinda; Comans, Tracy A.; Scuffham, Paul A.

In: BMC Neurology, Vol. 15, No. 1, 140, 19.08.2015.

Research output: Contribution to journalArticle

Boyd, RN, Baque, E, Piovesana, A, Ross, S, Ziviani, J, Sakzewski, L, Barber, L, Lloyd, O, McKinlay, L, Whittingham, K, Smith, AC, Rose, S, Fiori, S, Cunnington, R, Ware, R, Lewis, M, Comans, TA & Scuffham, PA 2015, 'Mitii™ ABI: Study protocol of a randomised controlled trial of a web-based multi-modal training program for children and adolescents with an Acquired Brain Injury (ABI)', BMC Neurology, vol. 15, no. 1, 140. https://doi.org/10.1186/s12883-015-0381-6
Boyd, Roslyn N. ; Baque, Emmah ; Piovesana, Adina ; Ross, Stephanie ; Ziviani, Jenny ; Sakzewski, Leanne ; Barber, Lee ; Lloyd, Owen ; McKinlay, Lynne ; Whittingham, Koa ; Smith, Anthony C. ; Rose, Stephen ; Fiori, Simona ; Cunnington, Ross ; Ware, Robert ; Lewis, Melinda ; Comans, Tracy A. ; Scuffham, Paul A. / Mitii™ ABI : Study protocol of a randomised controlled trial of a web-based multi-modal training program for children and adolescents with an Acquired Brain Injury (ABI). In: BMC Neurology. 2015 ; Vol. 15, No. 1.
@article{3f7f7e38ad1e490e95a1978c988c2303,
title = "Mitii™ ABI: Study protocol of a randomised controlled trial of a web-based multi-modal training program for children and adolescents with an Acquired Brain Injury (ABI)",
abstract = "Background: Acquired brain injury (ABI) refers to multiple disabilities arising from damage to the brain acquired after birth. Children with an ABI may experience physical, cognitive, social and emotional-behavioural impairments which can impact their ability to participate in activities of daily living (ADL). Recent developments in technology have led to the emergence of internet-delivered therapy programs. {"}Move it to improve it{"} (Mitii™) is a web-based multi-modal therapy that comprises upper limb (UL) and cognitive training within the context of meaningful physical activity. The proposed study aims to compare the efficacy of Mitii™ to usual care to improve ADL motor and processing skills, gross motor capacity, UL and executive functioning in a randomised waitlist controlled trial. Methods/Design: Sixty independently ambulant children (30 in each group) at least 12 months post ABI will be recruited to participate in this trial. Children will be matched in pairs at baseline and randomly allocated to receive either 20 weeks of Mitii™ training (30 min per day, six days a week, with a potential total dose of 60 h) immediately, or be waitlisted for 20 weeks. Outcomes will be assessed at baseline, immediately post-intervention and at 20 weeks post-intervention. The primary outcomes will be the Assessment of Motor and Process Skills and 30 s repetition maximum of functional strength exercises (sit-to-stand, step-ups and half kneel to stand). Measures of body structure and functions, activity, participation and quality of life will assess the efficacy of Mitii™ across all domains of the International Classification of Functioning, Disability and Health framework. A subset of children will undertake three tesla (3T) magnetic resonance imaging scans to evaluate functional neurovascular changes, structural imaging, diffusion imaging and resting state functional connectivity before and after intervention. Discussion: Mitii™ provides an alternative approach to deliver intensive therapy for children with an ABI in the convenience of the home environment. If Mitii™ is found to be effective, it may offer an accessible and inexpensive intervention option to increase therapy dose. Trial Registration:ANZCTR12613000403730",
keywords = "Acquired Brain Injury, Children, Executive Function, Motor Processing, Physical Activity, Protocol, Randomised Controlled Trial, Virtual Reality",
author = "Boyd, {Roslyn N.} and Emmah Baque and Adina Piovesana and Stephanie Ross and Jenny Ziviani and Leanne Sakzewski and Lee Barber and Owen Lloyd and Lynne McKinlay and Koa Whittingham and Smith, {Anthony C.} and Stephen Rose and Simona Fiori and Ross Cunnington and Robert Ware and Melinda Lewis and Comans, {Tracy A.} and Scuffham, {Paul A.}",
year = "2015",
month = "8",
day = "19",
doi = "10.1186/s12883-015-0381-6",
language = "English",
volume = "15",
journal = "BMC Neurology",
issn = "1471-2377",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Mitii™ ABI

T2 - Study protocol of a randomised controlled trial of a web-based multi-modal training program for children and adolescents with an Acquired Brain Injury (ABI)

AU - Boyd, Roslyn N.

AU - Baque, Emmah

AU - Piovesana, Adina

AU - Ross, Stephanie

AU - Ziviani, Jenny

AU - Sakzewski, Leanne

AU - Barber, Lee

AU - Lloyd, Owen

AU - McKinlay, Lynne

AU - Whittingham, Koa

AU - Smith, Anthony C.

AU - Rose, Stephen

AU - Fiori, Simona

AU - Cunnington, Ross

AU - Ware, Robert

AU - Lewis, Melinda

AU - Comans, Tracy A.

AU - Scuffham, Paul A.

PY - 2015/8/19

Y1 - 2015/8/19

N2 - Background: Acquired brain injury (ABI) refers to multiple disabilities arising from damage to the brain acquired after birth. Children with an ABI may experience physical, cognitive, social and emotional-behavioural impairments which can impact their ability to participate in activities of daily living (ADL). Recent developments in technology have led to the emergence of internet-delivered therapy programs. "Move it to improve it" (Mitii™) is a web-based multi-modal therapy that comprises upper limb (UL) and cognitive training within the context of meaningful physical activity. The proposed study aims to compare the efficacy of Mitii™ to usual care to improve ADL motor and processing skills, gross motor capacity, UL and executive functioning in a randomised waitlist controlled trial. Methods/Design: Sixty independently ambulant children (30 in each group) at least 12 months post ABI will be recruited to participate in this trial. Children will be matched in pairs at baseline and randomly allocated to receive either 20 weeks of Mitii™ training (30 min per day, six days a week, with a potential total dose of 60 h) immediately, or be waitlisted for 20 weeks. Outcomes will be assessed at baseline, immediately post-intervention and at 20 weeks post-intervention. The primary outcomes will be the Assessment of Motor and Process Skills and 30 s repetition maximum of functional strength exercises (sit-to-stand, step-ups and half kneel to stand). Measures of body structure and functions, activity, participation and quality of life will assess the efficacy of Mitii™ across all domains of the International Classification of Functioning, Disability and Health framework. A subset of children will undertake three tesla (3T) magnetic resonance imaging scans to evaluate functional neurovascular changes, structural imaging, diffusion imaging and resting state functional connectivity before and after intervention. Discussion: Mitii™ provides an alternative approach to deliver intensive therapy for children with an ABI in the convenience of the home environment. If Mitii™ is found to be effective, it may offer an accessible and inexpensive intervention option to increase therapy dose. Trial Registration:ANZCTR12613000403730

AB - Background: Acquired brain injury (ABI) refers to multiple disabilities arising from damage to the brain acquired after birth. Children with an ABI may experience physical, cognitive, social and emotional-behavioural impairments which can impact their ability to participate in activities of daily living (ADL). Recent developments in technology have led to the emergence of internet-delivered therapy programs. "Move it to improve it" (Mitii™) is a web-based multi-modal therapy that comprises upper limb (UL) and cognitive training within the context of meaningful physical activity. The proposed study aims to compare the efficacy of Mitii™ to usual care to improve ADL motor and processing skills, gross motor capacity, UL and executive functioning in a randomised waitlist controlled trial. Methods/Design: Sixty independently ambulant children (30 in each group) at least 12 months post ABI will be recruited to participate in this trial. Children will be matched in pairs at baseline and randomly allocated to receive either 20 weeks of Mitii™ training (30 min per day, six days a week, with a potential total dose of 60 h) immediately, or be waitlisted for 20 weeks. Outcomes will be assessed at baseline, immediately post-intervention and at 20 weeks post-intervention. The primary outcomes will be the Assessment of Motor and Process Skills and 30 s repetition maximum of functional strength exercises (sit-to-stand, step-ups and half kneel to stand). Measures of body structure and functions, activity, participation and quality of life will assess the efficacy of Mitii™ across all domains of the International Classification of Functioning, Disability and Health framework. A subset of children will undertake three tesla (3T) magnetic resonance imaging scans to evaluate functional neurovascular changes, structural imaging, diffusion imaging and resting state functional connectivity before and after intervention. Discussion: Mitii™ provides an alternative approach to deliver intensive therapy for children with an ABI in the convenience of the home environment. If Mitii™ is found to be effective, it may offer an accessible and inexpensive intervention option to increase therapy dose. Trial Registration:ANZCTR12613000403730

KW - Acquired Brain Injury

KW - Children

KW - Executive Function

KW - Motor Processing

KW - Physical Activity

KW - Protocol

KW - Randomised Controlled Trial

KW - Virtual Reality

UR - http://www.scopus.com/inward/record.url?scp=84939626485&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939626485&partnerID=8YFLogxK

U2 - 10.1186/s12883-015-0381-6

DO - 10.1186/s12883-015-0381-6

M3 - Article

AN - SCOPUS:84939626485

VL - 15

JO - BMC Neurology

JF - BMC Neurology

SN - 1471-2377

IS - 1

M1 - 140

ER -