Mitochondria and ALS: Implications from novel genes and pathways

Mauro Cozzolino, Alberto Ferri, Cristiana Valle, Maria Teresa Carrì

Research output: Contribution to journalArticle

Abstract

Evidence from patients with sporadic and familiar amyotrophic lateral sclerosis (ALS) and from models based on the overexpression of mutant SOD1 found in a small subset of patients, clearly point to mitochondrial damage as a relevant facet of this neurodegenerative condition. In this mini-review we provide a brief update on the subject in the light of newly discovered genes (such as TDP-43 and FUS/TLS) associated to familial ALS and of a deeper knowledge of the mechanisms of derangement of mitochondria. This article is part of a Special Issue entitled 'Mitochondrial function and dysfunction in neurodegeneration'.

Original languageEnglish
Pages (from-to)44-49
Number of pages6
JournalMolecular and Cellular Neuroscience
Volume55
DOIs
Publication statusPublished - Jul 2013

Keywords

  • Amyotrophic lateral sclerosis
  • Mitochondria
  • Oxidative stress

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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