Mitochondria and familial predisposition to breast cancer

Research output: Contribution to journalArticle

Abstract

Mitochondrial genome and functional alterations are related to various diseases including cancer. In all cases, the role of these organelles is associated with defects in oxidative energy metabolism and control of tumor-induced oxidative stress. The present study examines the involvement of mitochondrial DNA in cancer and in particular in breast cancer. Furthermore, since mitochondrial DNA is maternally inherited, hereditary breast cancer has been focused on.

Original languageEnglish
Pages (from-to)195-203
Number of pages9
JournalCurrent Genomics
Volume14
Issue number3
DOIs
Publication statusPublished - 2013

Keywords

  • Dna variations
  • Hereditary breast cancer
  • Mitochondrial dna
  • Mitochondrial haplogroup
  • Polymorphism

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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