Mitochondria and the link between neuroinflammation and neurodegeneration

Massimiliano Di Filippo, Davide Chiasserini, Alessandro Tozzi, Barbara Picconi, Paolo Calabresi

Research output: Contribution to journalArticle

Abstract

The innate immune response is thought to exert a dichotomous role in the brain. Indeed, although molecules of the innate immune response can promote repair mechanisms, during neuroinflammatory processes many harmful mediators are also released. Signs of neuroinflammation and neurodegeneration represent a ubiquitous pathological finding during the course of several different neurological diseases. Interestingly, it has been proposed that mitochondria may exert a crucial role in the pathogenesis of both inflammatory and neurodegenerative central nervous system disorders. In this review, we describe the mechanisms by which neuroinflammation and mitochondrial impairment may synergistically trigger a vicious cycle ultimately leading to neuronal death. In particular, we describe the close relationship existing among neuroinflammation, neurodegeneration, and mitochondrial impairment in three different widely-diffused neurological diseases in which these pathogenetic events coexist, namely multiple sclerosis, Parkinson's disease, and Alzheimer's disease.

Original languageEnglish
JournalJournal of Alzheimer's Disease
Volume20
Issue numberSUPPL.2
DOIs
Publication statusPublished - 2010

Keywords

  • Inflammation
  • mitochondria
  • multiple sclerosis
  • neurodegeneration
  • Parkinson's disease

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

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