Mitochondria are selective targets for the protective effects of heat shock against oxidative injury

B. S. Polla, S. Kantengwa, D. François, S. Salvioli, C. Franceschi, C. Marsac, A. Cossarizza

Research output: Contribution to journalArticle

Abstract

Heat shock (HS) proteins (HSPs) induce protection against a number of stresses distinct from HS, including reactive oxygen species. In the human premonocytic line U937, we investigated in whole cells the effects of preexposure to HS and exposure to hydrogen peroxide (H2O2) on mitochondrial membrane potential, mass, and ultrastructure. HS prevented H2O2-induced alterations in mitochondrial membrane potential and cristae formation while increasing expression of HSPs and the protein product of bcl-2. Protection correlated best with the expression of the 70-kDa HSP, hsp70. We propose that mitochondria represent a selective target for HS-mediated protection against oxidative injury.

Original languageEnglish
Pages (from-to)6458-6463
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume93
Issue number13
DOIs
Publication statusPublished - Jun 25 1996

Keywords

  • antioxidant
  • bcl-2
  • heat shock proteins
  • hydrogen peroxide
  • mitochondrial membrane potential

ASJC Scopus subject areas

  • Genetics
  • General

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