Mitochondria: Biogenesis and mitophagy balance in segregation and clonal expansion of mitochondrial DNA mutations

Valerio Carelli, Alessandra Maresca, Leonardo Caporali, Selena Trifunov, Claudia Zanna, Michela Rugolo

Research output: Contribution to journalArticle

Abstract

Mitochondria are cytoplasmic organelles containing their own multi-copy genome. They are organized in a highly dynamic network, resulting from balance between fission and fusion, which maintains homeostasis of mitochondrial mass through mitochondrial biogenesis and mitophagy. Mitochondrial DNA (mtDNA) mutates much faster than nuclear DNA. In particular, mtDNA point mutations and deletions may occur somatically and accumulate with aging, coexisting with the wild type, a condition known as heteroplasmy. Under specific circumstances, clonal expansion of mutant mtDNA may occur within single cells, causing a wide range of severe human diseases when mutant overcomes wild type. Furthermore, mtDNA deletions accumulate and clonally expand as a consequence of deleterious mutations in nuclear genes involved in mtDNA replication and maintenance, as well as in mitochondrial fusion genes (mitofusin-2 and OPA1), possibly implicating mtDNA nucleoids segregation. We here discuss how the intricacies of mitochondrial homeostasis impinge on the intracellular propagation of mutant mtDNA. This article is part of a Directed Issue entitled: Energy Metabolism Disorders and Therapies.

Original languageEnglish
Pages (from-to)21-24
Number of pages4
JournalInternational Journal of Biochemistry and Cell Biology
Volume63
DOIs
Publication statusPublished - Jun 1 2015

Keywords

  • Clonal expansion
  • Mitochondrial DNA
  • Mitochondrial DNA mutations
  • Mitophagy
  • Nucleoids

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Medicine(all)

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