Mitochondria, calcium and cell death: A deadly triad in neurodegeneration

Fulvio Celsi, Paola Pizzo, Marisa Brini, Sara Leo, Carmen Fotino, Paolo Pinton, Rosario Rizzuto

Research output: Contribution to journalArticlepeer-review

Abstract

Mitochondrial Ca2+ accumulation is a tightly controlled process, in turn regulating functions as diverse as aerobic metabolism and induction of cell death. The link between Ca2+ (dys)regulation, mitochondria and cellular derangement is particularly evident in neurodegenerative disorders, in which genetic models and environmental factors allowed to identify common traits in the pathogenic routes. We will here summarize: i) the current view of mechanisms and functions of mitochondrial Ca2+ homeostasis, ii) the basic principles of organelle Ca2+ transport, iii) the role of Ca2+ in neuronal cell death, and iv) the new information on the pathogenesis of Alzheimer's, Huntington's and Parkinson's diseases, highlighting the role of Ca2+ and mitochondria.

Original languageEnglish
Pages (from-to)335-344
Number of pages10
JournalBiochimica et Biophysica Acta - Bioenergetics
Volume1787
Issue number5
DOIs
Publication statusPublished - May 2009

Keywords

  • Alzheimer's disease
  • Calcium
  • Huntington's disease
  • Mitochondria
  • Neurodegenerative disease
  • Parkinson's disease

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology

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