Mitochondrial alterations and tendency to apoptosis in peripheral blood cells from children with Down syndrome

Erika Roat, Nicole Prada, Roberta Ferraresi, Chiara Giovenzana, Milena Nasi, Leonarda Troiano, Marcello Pinti, Elisa Nemes, Enrico Lugli, Ornella Biagioni, Mauro Mariotti, Luigi Ciacci, Ugo Consolo, Fiorella Balli, Andrea Cossarizza

Research output: Contribution to journalArticlepeer-review

Abstract

Different types of cells from subjects with Down syndrome (DS) have an increased susceptibility to cell death. We have studied apoptosis and mitochondrial (mt) membrane potential (ΔΨm) in peripheral blood mononuclear cells (PBMC) from DS children and age-matched healthy donors after in vitro treatment with apoptogenic molecules, along with mtDNA content. We found that PBMC from DS and healthy controls had a similar tendency to undergo apoptosis and a similar amount of mtDNA. However, in cells from DS subjects, mitochondria showed a higher loss of ΔΨm, underlying the presence of an increasing susceptibility of these organelles to damaging agents.

Original languageEnglish
Pages (from-to)521-525
Number of pages5
JournalFEBS Letters
Volume581
Issue number3
DOIs
Publication statusPublished - Feb 6 2007

Keywords

  • Apoptosis
  • Down syndrome
  • Mitochondria
  • mtDNA

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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