Mitochondrial biogenesis in mammals: The role of endogenous nitric oxide

Enzo Nisoli, Emilio Clementi, Clara Paolucci, Valeria Cozzi, Cristina Tonello, Clara Sciorati, Renata Bracale, Alessandra Valerio, Maura Francolini, Salvador Moncada, Michele O. Carruba

Research output: Contribution to journalArticle

Abstract

Nitric oxide was found to trigger mitochondrial biogenesis in cells as diverse as brown adipocytes and 3T3-L1, U937, and HeLa cells. This effect of nitric oxide was dependent on guanosine 3′,5′-monophosphate (cGMP) and was mediated by the induction of peroxisome proliferator-activated receptor γ coactivator 1α, a master regulator of mitochondrial biogenesis. Moreover, the mitochondrial biogenesis induced by exposure to cold was markedly reduced in brown adipose tissue of endothelial nitric oxide synthase null-mutant (eNOS-/-) mice, which had a reduced metabolic rate and accelerated weight gain as compared to wild-type mice. Thus, a nitric oxide-cGMP-dependent pathway controls mitochondrial biogenesis and body energy balance.

Original languageEnglish
Pages (from-to)896-899
Number of pages4
JournalScience
Volume299
Issue number5608
DOIs
Publication statusPublished - Feb 7 2003

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Organelle Biogenesis
Mammals
Nitric Oxide
Brown Adipocytes
3T3-L1 Cells
Guanosine Monophosphate
U937 Cells
Peroxisome Proliferator-Activated Receptors
Brown Adipose Tissue
Nitric Oxide Synthase Type III
HeLa Cells
Weight Gain

ASJC Scopus subject areas

  • General

Cite this

Nisoli, E., Clementi, E., Paolucci, C., Cozzi, V., Tonello, C., Sciorati, C., ... Carruba, M. O. (2003). Mitochondrial biogenesis in mammals: The role of endogenous nitric oxide. Science, 299(5608), 896-899. https://doi.org/10.1126/science.1079368

Mitochondrial biogenesis in mammals : The role of endogenous nitric oxide. / Nisoli, Enzo; Clementi, Emilio; Paolucci, Clara; Cozzi, Valeria; Tonello, Cristina; Sciorati, Clara; Bracale, Renata; Valerio, Alessandra; Francolini, Maura; Moncada, Salvador; Carruba, Michele O.

In: Science, Vol. 299, No. 5608, 07.02.2003, p. 896-899.

Research output: Contribution to journalArticle

Nisoli, E, Clementi, E, Paolucci, C, Cozzi, V, Tonello, C, Sciorati, C, Bracale, R, Valerio, A, Francolini, M, Moncada, S & Carruba, MO 2003, 'Mitochondrial biogenesis in mammals: The role of endogenous nitric oxide', Science, vol. 299, no. 5608, pp. 896-899. https://doi.org/10.1126/science.1079368
Nisoli E, Clementi E, Paolucci C, Cozzi V, Tonello C, Sciorati C et al. Mitochondrial biogenesis in mammals: The role of endogenous nitric oxide. Science. 2003 Feb 7;299(5608):896-899. https://doi.org/10.1126/science.1079368
Nisoli, Enzo ; Clementi, Emilio ; Paolucci, Clara ; Cozzi, Valeria ; Tonello, Cristina ; Sciorati, Clara ; Bracale, Renata ; Valerio, Alessandra ; Francolini, Maura ; Moncada, Salvador ; Carruba, Michele O. / Mitochondrial biogenesis in mammals : The role of endogenous nitric oxide. In: Science. 2003 ; Vol. 299, No. 5608. pp. 896-899.
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