Mitochondrial complex I deficiency and cardiovascular diseases: current evidence and future directions

Research output: Contribution to journalReview article

Abstract

Compelling evidence demonstrates the emerging role of mitochondrial complex I deficiency in the onset and development of cardiovascular diseases (CVDs). In particular, defects in single subunits of mitochondrial complex I have been associated with cardiac hypertrophy, ischemia/reperfusion injury, as well as diabetic complications and stroke in pre-clinical studies. Moreover, data obtained in humans revealed that genes coding for complex I proteins were associated with different CVDs. In this review, we discuss recent experimental studies that underline the contributory role of mitochondrial complex I deficiency in the etiopathogenesis of several CVDs, with a particular focus on those involving loss of function models of mitochondrial complex I. We also discuss human studies and potential therapeutic strategies able to rescue mitochondrial function in CVDs.

Original languageEnglish
Pages (from-to)579-591
Number of pages13
JournalJournal of Molecular Medicine
Volume97
Issue number5
DOIs
Publication statusPublished - May 2019

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