Mitochondrial dementia: A sporadic case of progressive cognitive and behavioral decline with hearing loss due to the rare m.3291T>C MELAS mutation

Ettore Salsano, Anna Rita Giovagnoli, Lucia Morandi, Carmelo MacCagnano, Eleonora Lamantea, Chiara Marchesi, Massimo Zeviani, Davide Pareyson

Research output: Contribution to journalArticle

Abstract

We report the case of a 23-year-old Italian female harboring the rare m.3291T>C mutation in the MT-TL1 gene, that encodes the mitochondrial transfer RNA for leucine 1 (UUA/G). MT-TL1 mutations usually cause the MELAS (mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes) syndrome. Our patient, however, suffered from a non-syndromic mitochondrial disorder (MID), clinically characterized by progressive cognitive and behavioral decline, and hearing loss; brain MRI disclosed diffuse supratentorial and infratentorial atrophy; EKG revealed a Wolff-Parkinson-White syndrome; combined neuroleptic and antidepressant treatment markedly improved her behavioral symptoms. This case expands the clinical spectrum of non-syndromic MIDs, and further confirms that no obvious genotype-phenotype correlation exists for the m.3291T>C DNA mutation; indeed, this mutation has been previously reported in a Japanese child, who suffered from MELAS, and in an Italian child, who presented an apparently isolated mild myopathy. Moreover, it supports the hypothesis that at least in MT-TL1-related MIDs, dementia may be caused by a progressive neurodegenerative process, rather than by injury accumulation due to stroke-like episodes. Finally, our case suggests that common neuroleptic and antidepressant drugs may be clinically efficacious in the management of psychiatric symptoms associated with MIDs.

Original languageEnglish
Pages (from-to)165-168
Number of pages4
JournalJournal of the Neurological Sciences
Volume300
Issue number1-2
DOIs
Publication statusPublished - Jan 15 2011

Keywords

  • Dementia
  • Hearing loss
  • MELAS syndrome
  • Mitochondrial disorders
  • Olanzapine
  • Wolff-Parkinson-White syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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