Mitochondrial diseases: A cross-talk between mitochondrial and nuclear genomes

Antonella Spinazzola, Massimo Zeviani

Research output: Chapter in Book/Report/Conference proceedingConference contribution


More than one billion years ago, mitochondria were free-living prokaryotic organisms with their own DNA. However, during the evolution, ancestral genes have been transferred from the mitochondrial to the nuclear genome so that mtDNA became dependent on numerous nucleus-encoded factors for its integrity, replication and expression. Mutations in any of these factors may alter the cross-talk between the two genomes and cause Mendelian diseases that affect mtDNA integrity or expression.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
Number of pages16
Publication statusPublished - 2009

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)00652598


  • Mitochondrial disease
  • Mitochondrial DNA
  • Mitochondrion cross-talk
  • mtDNA depletion
  • mtDNA multiple deletions
  • Nucleus

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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