Mitochondrial diseases: A cross-talk between mitochondrial and nuclear genomes

Antonella Spinazzola, Massimo Zeviani

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

More than one billion years ago, mitochondria were free-living prokaryotic organisms with their own DNA. However, during the evolution, ancestral genes have been transferred from the mitochondrial to the nuclear genome so that mtDNA became dependent on numerous nucleus-encoded factors for its integrity, replication and expression. Mutations in any of these factors may alter the cross-talk between the two genomes and cause Mendelian diseases that affect mtDNA integrity or expression.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
Pages69-84
Number of pages16
Volume652
DOIs
Publication statusPublished - 2009

Publication series

NameAdvances in Experimental Medicine and Biology
Volume652
ISSN (Print)00652598

Fingerprint

Mitochondrial Diseases
Mitochondrial Genome
Mitochondrial DNA
Genes
Genome
Mitochondria
Mutation
DNA

Keywords

  • Mitochondrial disease
  • Mitochondrial DNA
  • Mitochondrion cross-talk
  • mtDNA depletion
  • mtDNA multiple deletions
  • Nucleus

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Spinazzola, A., & Zeviani, M. (2009). Mitochondrial diseases: A cross-talk between mitochondrial and nuclear genomes. In Advances in Experimental Medicine and Biology (Vol. 652, pp. 69-84). (Advances in Experimental Medicine and Biology; Vol. 652). https://doi.org/10.1007/978-90-481-2813-6_6

Mitochondrial diseases : A cross-talk between mitochondrial and nuclear genomes. / Spinazzola, Antonella; Zeviani, Massimo.

Advances in Experimental Medicine and Biology. Vol. 652 2009. p. 69-84 (Advances in Experimental Medicine and Biology; Vol. 652).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Spinazzola, A & Zeviani, M 2009, Mitochondrial diseases: A cross-talk between mitochondrial and nuclear genomes. in Advances in Experimental Medicine and Biology. vol. 652, Advances in Experimental Medicine and Biology, vol. 652, pp. 69-84. https://doi.org/10.1007/978-90-481-2813-6_6
Spinazzola A, Zeviani M. Mitochondrial diseases: A cross-talk between mitochondrial and nuclear genomes. In Advances in Experimental Medicine and Biology. Vol. 652. 2009. p. 69-84. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-90-481-2813-6_6
Spinazzola, Antonella ; Zeviani, Massimo. / Mitochondrial diseases : A cross-talk between mitochondrial and nuclear genomes. Advances in Experimental Medicine and Biology. Vol. 652 2009. pp. 69-84 (Advances in Experimental Medicine and Biology).
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