Mitochondrial DNA 4977 bp deletion and OH8dG levels correlate in the brain of aged subjects but not Alzheimer's disease patients

Angela Maria Serena Lezza, Patrizia Mecocci, Antonella Cormio, M. Flint Beal, Antonio Cherubini, Palmiro Cantatore, Umberto Senin, Maria Nicola Gadaleta

Research output: Contribution to journalArticlepeer-review

Abstract

The levels of mitochondrial DNA 4977 bp deletion (mtDNA4977) and mitochondrial DNA 8'-hydroxy-2'-deoxyguanosine (OH8dG) were determined in the same samples from two brain areas of healthy subjects and Alzheimer's disease (AD) patients. A positive correlation between the age-related increases of mtDNA4977 and of OH8dG levels was found in the brain of healthy individuals. On the contrary, in both brain areas of AD patients, mtDNA4977 levels were very low in the presence of high OH8dG amounts. These results might be explained assuming that the increase of OH8dG above a threshold level, as in AD patients, implies consequences for mtDNA replication and neuronal cell survival.

Original languageEnglish
Pages (from-to)1083-1088
Number of pages6
JournalFASEB Journal
Volume13
Issue number9
Publication statusPublished - 1999

Keywords

  • Aging
  • mtDNA deletions
  • mtDNA oxidative damage
  • Neurodegenerative disease

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

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