Mitochondrial dynamics in cancer and neurodegenerative and neuroinflammatory diseases

Mauro Corrado, Luca Scorrano, Silvia Campello

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Mitochondria are key organelles in the cell, hosting essential functions, from biosynthetic and metabolic pathways, to oxidative phosphorylation and ATP production, from calcium buffering to red-ox homeostasis and apoptotic signalling pathways. Mitochondria are also dynamic organelles, continuously fusing and dividing, and their localization, size and trafficking are finely regulated. Moreover, in recent decades, alterations in mitochondrial function and dynamics have been implicated in an increasing number of diseases. In this review, we focus on the relationship clarified hitherto between mitochondrial dynamics and cancer, neurodegenerative and neuroinflammatory diseases.

Original languageEnglish
Article number729290
JournalInternational Journal of Cell Biology
DOIs
Publication statusPublished - 2012

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Mitochondrial Dynamics
Neurodegenerative Diseases
Organelles
Mitochondria
Oxidative Phosphorylation
Biosynthetic Pathways
Metabolic Networks and Pathways
Neoplasms
Homeostasis
Adenosine Triphosphate
Calcium

ASJC Scopus subject areas

  • Cell Biology

Cite this

Mitochondrial dynamics in cancer and neurodegenerative and neuroinflammatory diseases. / Corrado, Mauro; Scorrano, Luca; Campello, Silvia.

In: International Journal of Cell Biology, 2012.

Research output: Contribution to journalArticle

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