Mitochondrial dynamics: Molecular mechanisms, related primary mitochondrial disorders and therapeutic approaches

Michela Di Nottia, Daniela Verrigni, Alessandra Torraco, Teresa Rizza, Enrico Bertini, Rosalba Carrozzo

Research output: Contribution to journalReview articlepeer-review

Abstract

Mitochondria do not exist as individual entities in the cell—conversely, they constitute an interconnected community governed by the constant and opposite process of fission and fusion. The mitochondrial fission leads to the formation of smaller mitochondria, promoting the biogenesis of new organelles. On the other hand, following the fusion process, mitochondria appear as longer and interconnected tubules, which enhance the communication with other organelles. Both fission and fusion are carried out by a small number of highly conserved guanosine triphosphatase proteins and their interactors. Disruption of this equilibrium has been associated with several pathological condi-tions, ranging from cancer to neurodegeneration, and mutations in genes involved in mitochondrial fission and fusion have been reported to be the cause of a subset of neurogenetic disorders.

Original languageEnglish
Article number247
Pages (from-to)1-24
Number of pages24
JournalGenes
Volume12
Issue number2
DOIs
Publication statusPublished - Feb 2021

Keywords

  • Mitochondrial diseases
  • Mitochondrial dynamics
  • Therapeutic approaches

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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