Mitochondrial dysfunction in hepatitis C virus infection

C. Piccoli, R. Scrima, A. D'Aprile, M. Ripoli, L. Lecce, D. Boffoli, N. Capitanio

Research output: Contribution to journalArticle

Abstract

The mechanisms of liver injury in chronic hepatitis C virus (HCV) infection are poorly understood though HCV induces a state of hepatic oxidative stress that is more pronounced than that present in many other inflammatory diseases. This mini-review will focus on recent findings revealing an unexpected role of mitochondria in providing a central role in the innate immunity and in addition will illustrate the application of stably transfected human-derived cell lines, inducibly expressing the entire HCV open reading frame for in vitro studies on mitochondria. Results obtained by a comparative analysis of the respiratory chain complexes activities along with mitochondrial morpho-functional confocal microscopy imaging show a detrimental effect of HCV proteins on the cell oxidative metabolism with specific inhibition of complex I activity, decrease of mtΔΨ, increased production of reactive oxygen species. A possible de-regulation of calcium recycling between the endoplasmic reticulum and the mitochondrial network is discussed to provide new insights in the pathogenesis of hepatitis C.

Original languageEnglish
Pages (from-to)1429-1437
Number of pages9
JournalBiochimica et Biophysica Acta - Bioenergetics
Volume1757
Issue number9-10
DOIs
Publication statusPublished - Sep 2006

Fingerprint

Virus Diseases
Viruses
Hepacivirus
Mitochondria
Enzyme inhibition
Oxidative stress
Deregulation
Confocal microscopy
Liver
Recycling
Chronic Hepatitis C
Hepatitis C
Electron Transport
Innate Immunity
Metabolism
Confocal Microscopy
Endoplasmic Reticulum
Open Reading Frames
Reactive Oxygen Species
Oxidative Stress

Keywords

  • Calcium
  • Complex I
  • Endoplasmic reticulum
  • HCV
  • Inducible gene expression
  • Mitochondria
  • Reactive oxygen specie

ASJC Scopus subject areas

  • Biophysics

Cite this

Piccoli, C., Scrima, R., D'Aprile, A., Ripoli, M., Lecce, L., Boffoli, D., & Capitanio, N. (2006). Mitochondrial dysfunction in hepatitis C virus infection. Biochimica et Biophysica Acta - Bioenergetics, 1757(9-10), 1429-1437. https://doi.org/10.1016/j.bbabio.2006.05.018

Mitochondrial dysfunction in hepatitis C virus infection. / Piccoli, C.; Scrima, R.; D'Aprile, A.; Ripoli, M.; Lecce, L.; Boffoli, D.; Capitanio, N.

In: Biochimica et Biophysica Acta - Bioenergetics, Vol. 1757, No. 9-10, 09.2006, p. 1429-1437.

Research output: Contribution to journalArticle

Piccoli, C, Scrima, R, D'Aprile, A, Ripoli, M, Lecce, L, Boffoli, D & Capitanio, N 2006, 'Mitochondrial dysfunction in hepatitis C virus infection', Biochimica et Biophysica Acta - Bioenergetics, vol. 1757, no. 9-10, pp. 1429-1437. https://doi.org/10.1016/j.bbabio.2006.05.018
Piccoli C, Scrima R, D'Aprile A, Ripoli M, Lecce L, Boffoli D et al. Mitochondrial dysfunction in hepatitis C virus infection. Biochimica et Biophysica Acta - Bioenergetics. 2006 Sep;1757(9-10):1429-1437. https://doi.org/10.1016/j.bbabio.2006.05.018
Piccoli, C. ; Scrima, R. ; D'Aprile, A. ; Ripoli, M. ; Lecce, L. ; Boffoli, D. ; Capitanio, N. / Mitochondrial dysfunction in hepatitis C virus infection. In: Biochimica et Biophysica Acta - Bioenergetics. 2006 ; Vol. 1757, No. 9-10. pp. 1429-1437.
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