Mitochondrial injury and protection in ischemic pre-and postconditioning

Fabio Di Lisa, Marcella Canton, Andrea Carpi, Nina Kaludercic, Roberta Menabò, Sara Menazza, Martina Semenzato

Research output: Contribution to journalArticlepeer-review

Abstract

Mitochondrial damage is a determining factor in causing loss of cardiomyocyte function and viability, yet a mild degree of mitochondrial dysfunction appears to underlie cardioprotection against injury caused by postischemic reperfusion. This review is focused on two major mechanisms of mitochondrial dysfunction, namely, oxidative stress and opening of the mitochondrial permeability transition pore. The formation of reactive oxygen species in mitochondria will be analyzed with regard to factors controlling mitochondrial permeability transition pore opening. Finally, these mitochondrial processes are analyzed with respect to cardioprotection afforded by ischemic pre-and postconditioning.

Original languageEnglish
Pages (from-to)881-891
Number of pages11
JournalAntioxidants and Redox Signaling
Volume14
Issue number5
DOIs
Publication statusPublished - Mar 1 2011

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Physiology
  • Clinical Biochemistry

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