Mitochondrial Interactome: A Focus on Antiviral Signaling Pathways

Research output: Contribution to journalReview article

Abstract

In the last years, proteomics has represented a valuable approach to elucidate key aspects in the regulation of type I/III interferons (IFNs) and autophagy, two main processes involved in the response to viral infection, to unveil the molecular strategies that viruses have evolved to counteract these processes. Besides their main metabolic roles, mitochondria are well recognized as pivotal organelles in controlling signaling pathways essential to restrain viral infections. In particular, a major role in antiviral defense is played by mitochondrial antiviral signaling (MAVS) protein, an adaptor protein that coordinates the activation of IFN inducing pathways and autophagy at the mitochondrial level. Here, we provide an overview of how mass spectrometry-based studies of protein–protein interactions and post-translational modifications (PTMs) have fostered our understanding of the molecular mechanisms that control the mitochondria-mediated antiviral immunity.

Original languageEnglish
Article number8
JournalFrontiers in Cell and Developmental Biology
Volume8
DOIs
Publication statusPublished - Feb 14 2020

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Keywords

  • mitochondria
  • mitochondrial antiviral signaling protein
  • proteomics
  • retinoic acid-inducible gene I
  • RNA virus infection

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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