Mitochondrial pathways for ROS formation and myocardial injury: The relevance of p66Shc and monoamine oxidase

Fabio Di Lisa, Nina Kaludercic, Andrea Carpi, Roberta Menabò, Marco Giorgio

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Although mitochondria are considered the most relevant site for the formation of reactive oxygen species (ROS) in cardiac myocytes, a major and unsolved issue is where ROS are generated in mitochondria. Respiratory chain is generally indicated as a main site for ROS formation. However, other mitochondrial components are likely to contribute to ROS generation. Recent reports highlight the relevance of monoamine oxidases (MAO) and p66Shc. The importance of these systems in the irreversibility of ischemic heart injury will be discussed along with the cardioprotective effects elicited by both MAO inhibition and p66Shc knockout. Finally, recent evidence will be reviewed that highlight the relevance of mitochondrial ROS formation also in myocardial failure and atherosclerosis.

Original languageEnglish
Pages (from-to)131-139
Number of pages9
JournalBasic Research in Cardiology
Volume104
Issue number2
DOIs
Publication statusPublished - 2009

Fingerprint

Monoamine Oxidase
Reactive Oxygen Species
Wounds and Injuries
Mitochondria
Heart Injuries
Electron Transport
Cardiac Myocytes
Atherosclerosis
Heart Failure

Keywords

  • Mitochondria
  • Monoamineoxidase
  • Oxidative stress
  • p66

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)
  • Physiology

Cite this

Mitochondrial pathways for ROS formation and myocardial injury : The relevance of p66Shc and monoamine oxidase. / Di Lisa, Fabio; Kaludercic, Nina; Carpi, Andrea; Menabò, Roberta; Giorgio, Marco.

In: Basic Research in Cardiology, Vol. 104, No. 2, 2009, p. 131-139.

Research output: Contribution to journalArticle

Di Lisa, Fabio ; Kaludercic, Nina ; Carpi, Andrea ; Menabò, Roberta ; Giorgio, Marco. / Mitochondrial pathways for ROS formation and myocardial injury : The relevance of p66Shc and monoamine oxidase. In: Basic Research in Cardiology. 2009 ; Vol. 104, No. 2. pp. 131-139.
@article{7aa750ca151148228effb2f720283729,
title = "Mitochondrial pathways for ROS formation and myocardial injury: The relevance of p66Shc and monoamine oxidase",
abstract = "Although mitochondria are considered the most relevant site for the formation of reactive oxygen species (ROS) in cardiac myocytes, a major and unsolved issue is where ROS are generated in mitochondria. Respiratory chain is generally indicated as a main site for ROS formation. However, other mitochondrial components are likely to contribute to ROS generation. Recent reports highlight the relevance of monoamine oxidases (MAO) and p66Shc. The importance of these systems in the irreversibility of ischemic heart injury will be discussed along with the cardioprotective effects elicited by both MAO inhibition and p66Shc knockout. Finally, recent evidence will be reviewed that highlight the relevance of mitochondrial ROS formation also in myocardial failure and atherosclerosis.",
keywords = "Mitochondria, Monoamineoxidase, Oxidative stress, p66",
author = "{Di Lisa}, Fabio and Nina Kaludercic and Andrea Carpi and Roberta Menab{\`o} and Marco Giorgio",
year = "2009",
doi = "10.1007/s00395-009-0008-4",
language = "English",
volume = "104",
pages = "131--139",
journal = "Basic Research in Cardiology",
issn = "0300-8428",
publisher = "D. Steinkopff-Verlag",
number = "2",

}

TY - JOUR

T1 - Mitochondrial pathways for ROS formation and myocardial injury

T2 - The relevance of p66Shc and monoamine oxidase

AU - Di Lisa, Fabio

AU - Kaludercic, Nina

AU - Carpi, Andrea

AU - Menabò, Roberta

AU - Giorgio, Marco

PY - 2009

Y1 - 2009

N2 - Although mitochondria are considered the most relevant site for the formation of reactive oxygen species (ROS) in cardiac myocytes, a major and unsolved issue is where ROS are generated in mitochondria. Respiratory chain is generally indicated as a main site for ROS formation. However, other mitochondrial components are likely to contribute to ROS generation. Recent reports highlight the relevance of monoamine oxidases (MAO) and p66Shc. The importance of these systems in the irreversibility of ischemic heart injury will be discussed along with the cardioprotective effects elicited by both MAO inhibition and p66Shc knockout. Finally, recent evidence will be reviewed that highlight the relevance of mitochondrial ROS formation also in myocardial failure and atherosclerosis.

AB - Although mitochondria are considered the most relevant site for the formation of reactive oxygen species (ROS) in cardiac myocytes, a major and unsolved issue is where ROS are generated in mitochondria. Respiratory chain is generally indicated as a main site for ROS formation. However, other mitochondrial components are likely to contribute to ROS generation. Recent reports highlight the relevance of monoamine oxidases (MAO) and p66Shc. The importance of these systems in the irreversibility of ischemic heart injury will be discussed along with the cardioprotective effects elicited by both MAO inhibition and p66Shc knockout. Finally, recent evidence will be reviewed that highlight the relevance of mitochondrial ROS formation also in myocardial failure and atherosclerosis.

KW - Mitochondria

KW - Monoamineoxidase

KW - Oxidative stress

KW - p66

UR - http://www.scopus.com/inward/record.url?scp=62249115660&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=62249115660&partnerID=8YFLogxK

U2 - 10.1007/s00395-009-0008-4

DO - 10.1007/s00395-009-0008-4

M3 - Article

C2 - 19242637

AN - SCOPUS:62249115660

VL - 104

SP - 131

EP - 139

JO - Basic Research in Cardiology

JF - Basic Research in Cardiology

SN - 0300-8428

IS - 2

ER -