Abstract
Although mitochondria are considered the most relevant site for the formation of reactive oxygen species (ROS) in cardiac myocytes, a major and unsolved issue is where ROS are generated in mitochondria. Respiratory chain is generally indicated as a main site for ROS formation. However, other mitochondrial components are likely to contribute to ROS generation. Recent reports highlight the relevance of monoamine oxidases (MAO) and p66Shc. The importance of these systems in the irreversibility of ischemic heart injury will be discussed along with the cardioprotective effects elicited by both MAO inhibition and p66Shc knockout. Finally, recent evidence will be reviewed that highlight the relevance of mitochondrial ROS formation also in myocardial failure and atherosclerosis.
| Original language | English |
|---|---|
| Pages (from-to) | 131-139 |
| Number of pages | 9 |
| Journal | Basic Research in Cardiology |
| Volume | 104 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2009 |
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Keywords
- Mitochondria
- Monoamineoxidase
- Oxidative stress
- p66
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Physiology (medical)
- Physiology
Cite this
Mitochondrial pathways for ROS formation and myocardial injury : The relevance of p66Shc and monoamine oxidase. / Di Lisa, Fabio; Kaludercic, Nina; Carpi, Andrea; Menabò, Roberta; Giorgio, Marco.
In: Basic Research in Cardiology, Vol. 104, No. 2, 2009, p. 131-139.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mitochondrial pathways for ROS formation and myocardial injury
T2 - The relevance of p66Shc and monoamine oxidase
AU - Di Lisa, Fabio
AU - Kaludercic, Nina
AU - Carpi, Andrea
AU - Menabò, Roberta
AU - Giorgio, Marco
PY - 2009
Y1 - 2009
N2 - Although mitochondria are considered the most relevant site for the formation of reactive oxygen species (ROS) in cardiac myocytes, a major and unsolved issue is where ROS are generated in mitochondria. Respiratory chain is generally indicated as a main site for ROS formation. However, other mitochondrial components are likely to contribute to ROS generation. Recent reports highlight the relevance of monoamine oxidases (MAO) and p66Shc. The importance of these systems in the irreversibility of ischemic heart injury will be discussed along with the cardioprotective effects elicited by both MAO inhibition and p66Shc knockout. Finally, recent evidence will be reviewed that highlight the relevance of mitochondrial ROS formation also in myocardial failure and atherosclerosis.
AB - Although mitochondria are considered the most relevant site for the formation of reactive oxygen species (ROS) in cardiac myocytes, a major and unsolved issue is where ROS are generated in mitochondria. Respiratory chain is generally indicated as a main site for ROS formation. However, other mitochondrial components are likely to contribute to ROS generation. Recent reports highlight the relevance of monoamine oxidases (MAO) and p66Shc. The importance of these systems in the irreversibility of ischemic heart injury will be discussed along with the cardioprotective effects elicited by both MAO inhibition and p66Shc knockout. Finally, recent evidence will be reviewed that highlight the relevance of mitochondrial ROS formation also in myocardial failure and atherosclerosis.
KW - Mitochondria
KW - Monoamineoxidase
KW - Oxidative stress
KW - p66
UR - http://www.scopus.com/inward/record.url?scp=62249115660&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=62249115660&partnerID=8YFLogxK
U2 - 10.1007/s00395-009-0008-4
DO - 10.1007/s00395-009-0008-4
M3 - Article
C2 - 19242637
AN - SCOPUS:62249115660
VL - 104
SP - 131
EP - 139
JO - Basic Research in Cardiology
JF - Basic Research in Cardiology
SN - 0300-8428
IS - 2
ER -