Mitochondrial pathways for ROS formation and myocardial injury: The relevance of p66Shc and monoamine oxidase

Fabio Di Lisa, Nina Kaludercic, Andrea Carpi, Roberta Menabò, Marco Giorgio

Research output: Contribution to journalArticlepeer-review

Abstract

Although mitochondria are considered the most relevant site for the formation of reactive oxygen species (ROS) in cardiac myocytes, a major and unsolved issue is where ROS are generated in mitochondria. Respiratory chain is generally indicated as a main site for ROS formation. However, other mitochondrial components are likely to contribute to ROS generation. Recent reports highlight the relevance of monoamine oxidases (MAO) and p66Shc. The importance of these systems in the irreversibility of ischemic heart injury will be discussed along with the cardioprotective effects elicited by both MAO inhibition and p66Shc knockout. Finally, recent evidence will be reviewed that highlight the relevance of mitochondrial ROS formation also in myocardial failure and atherosclerosis.

Original languageEnglish
Pages (from-to)131-139
Number of pages9
JournalBasic Research in Cardiology
Volume104
Issue number2
DOIs
Publication statusPublished - 2009

Keywords

  • Mitochondria
  • Monoamineoxidase
  • Oxidative stress
  • p66

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)
  • Physiology

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