Mitochondrial quality control mechanisms as molecular targets in cardiac ageing

Anna Picca, Robert T. Mankowski, Jonathon L. Burman, Luca Donisi, Jae Sung Kim, Emanuele Marzetti, Christiaan Leeuwenburgh

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Cardiovascular disease is the leading cause of morbidity and mortality worldwide. Advancing age is a major risk factor for developing cardiovascular disease because of the lifelong exposure to cardiovascular risk factors and specific alterations affecting the heart and the vasculature during ageing. Indeed, the ageing heart is characterized by structural and functional changes that are caused by alterations in fundamental cardiomyocyte functions. In particular, the myocardium is heavily dependent on mitochondrial oxidative metabolism and is especially susceptible to mitochondrial dysfunction. Indeed, primary alterations in mitochondrial function, which are subsequently amplified by defective quality control mechanisms, are considered to be major contributing factors to cardiac senescence. In this Review, we discuss the mechanisms linking defective mitochondrial quality control mechanisms (that is, proteostasis, biogenesis, dynamics, and autophagy) to organelle dysfunction in the context of cardiac ageing. We also illustrate relevant molecular pathways that might be exploited for the prevention and treatment of age-related heart dysfunction.

Original languageEnglish
Pages (from-to)543-554
Number of pages12
JournalNature Reviews Cardiology
Volume15
Issue number9
DOIs
Publication statusPublished - Sep 1 2018

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Quality Control
Cardiovascular Diseases
Autophagy
Cardiac Myocytes
Organelles
Myocardium
Morbidity
Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Picca, A., Mankowski, R. T., Burman, J. L., Donisi, L., Kim, J. S., Marzetti, E., & Leeuwenburgh, C. (2018). Mitochondrial quality control mechanisms as molecular targets in cardiac ageing. Nature Reviews Cardiology, 15(9), 543-554. https://doi.org/10.1038/s41569-018-0059-z

Mitochondrial quality control mechanisms as molecular targets in cardiac ageing. / Picca, Anna; Mankowski, Robert T.; Burman, Jonathon L.; Donisi, Luca; Kim, Jae Sung; Marzetti, Emanuele; Leeuwenburgh, Christiaan.

In: Nature Reviews Cardiology, Vol. 15, No. 9, 01.09.2018, p. 543-554.

Research output: Contribution to journalReview article

Picca, A, Mankowski, RT, Burman, JL, Donisi, L, Kim, JS, Marzetti, E & Leeuwenburgh, C 2018, 'Mitochondrial quality control mechanisms as molecular targets in cardiac ageing', Nature Reviews Cardiology, vol. 15, no. 9, pp. 543-554. https://doi.org/10.1038/s41569-018-0059-z
Picca, Anna ; Mankowski, Robert T. ; Burman, Jonathon L. ; Donisi, Luca ; Kim, Jae Sung ; Marzetti, Emanuele ; Leeuwenburgh, Christiaan. / Mitochondrial quality control mechanisms as molecular targets in cardiac ageing. In: Nature Reviews Cardiology. 2018 ; Vol. 15, No. 9. pp. 543-554.
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