TY - JOUR
T1 - Mitophagy and oxidative stress in cancer and aging
T2 - Focus on sirtuins and nanomaterials
AU - Vernucci, Enza
AU - Tomino, Carlo
AU - Molinari, Francesca
AU - Limongi, Dolores
AU - Aventaggiato, Michele
AU - Sansone, Luigi
AU - Tafani, Marco
AU - Russo, Matteo A.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Mitochondria are the cellular center of energy production and of several important metabolic processes. Mitochondrion health is maintained with a substantial intervention of mitophagy, a process of macroautophagy that degrades selectively dysfunctional and irreversibly damaged organelles. Because of its crucial duty, alteration in mitophagy can cause functional and structural adjustment in the mitochondria, changes in energy production, loss of cellular adaptation, and cell death. In this review, we discuss the dual role that mitophagy plays in cancer and age-related pathologies, as a consequence of oxidative stress, evidencing the triggering stimuli and mechanisms and suggesting the molecular targets for its therapeutic control. Finally, a section has been dedicated to the interplay between mitophagy and therapies using nanoparticles that are the new frontier for a direct and less invasive strategy.
AB - Mitochondria are the cellular center of energy production and of several important metabolic processes. Mitochondrion health is maintained with a substantial intervention of mitophagy, a process of macroautophagy that degrades selectively dysfunctional and irreversibly damaged organelles. Because of its crucial duty, alteration in mitophagy can cause functional and structural adjustment in the mitochondria, changes in energy production, loss of cellular adaptation, and cell death. In this review, we discuss the dual role that mitophagy plays in cancer and age-related pathologies, as a consequence of oxidative stress, evidencing the triggering stimuli and mechanisms and suggesting the molecular targets for its therapeutic control. Finally, a section has been dedicated to the interplay between mitophagy and therapies using nanoparticles that are the new frontier for a direct and less invasive strategy.
UR - http://www.scopus.com/inward/record.url?scp=85068360090&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85068360090&partnerID=8YFLogxK
U2 - 10.1155/2019/6387357
DO - 10.1155/2019/6387357
M3 - Review article
C2 - 31210843
AN - SCOPUS:85068360090
VL - 2019
JO - Oxidative Medicine and Cellular Longevity
JF - Oxidative Medicine and Cellular Longevity
SN - 1942-0900
M1 - 6387357
ER -