Mitotic oscillators as MP graphs

Giuditta Franco, Pietro Hiram Guzzi, Vincenzo Manca, Tommaso Mazza

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper proposes a model in terms of metabolic P graphs of a few important processes occurring during the biological phase where the choice is made to begin again mitosis or to arrest it. The cellular processes during this phase turn out to be especially interesting in the case of DNA damage, which triggers a specific destruction of Cdc25A phosphatase. It has important implications to understand the role of cell cycle checkpoints and the mechanism(s) guiding the proliferation of UV-resistant tumored cells. The formalism of metabolic P graphs highlights the relevant information of the biological network dynamics, and the individuation of few parameters rules the basic mechanisms of Cdc25A degradation, involving a couple of important mitotic oscillators.

Original languageEnglish
Title of host publicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Pages382-394
Number of pages13
Volume4361 LNCS
DOIs
Publication statusPublished - 2006
Event7th International Workshop on Membrane Computing, WMC 2006 - Leiden, Netherlands
Duration: Jul 17 2006Jul 21 2006

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume4361 LNCS
ISSN (Print)03029743
ISSN (Electronic)16113349

Other

Other7th International Workshop on Membrane Computing, WMC 2006
CountryNetherlands
CityLeiden
Period7/17/067/21/06

ASJC Scopus subject areas

  • Computer Science(all)
  • Theoretical Computer Science

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