Mitozolomide activity on human cancer cells in vitro

E. Erba, S. Pepe, P. Ubezio, A. Lorico, L. Morasca, C. Mangioni, F. Landoni, M. D'Incalci

Research output: Contribution to journalArticlepeer-review

Abstract

The growth inhibitory effects, the reduction of [3H]-TdR incorporation and the perturbation of the cell cyle induced by the new agent mitozolomide on the M14 human melanoma cell line and on the SW626 human ovarian cancer cell line were compared to those produced by BCNU. Flow cytometry showed an interesting difference: at the high concentration mitozolomide induced an accumulation of cells in S middle and S late-G2-M phase of the cell cycle whereas BCNU caused only a block in S late-G2-M. Further studies were aimed at investigating the susceptibility of freshly isolated human ovarian cancer cells to pharmacologically reasonable mitozolomide concentrations. Only in one out of 16 primary cultures of human ovarian cancers was mitozolomide able to induce cell cycle perturbation, suggesting that ovarian carcinoma cells may not be sensitive to this drug.

Original languageEnglish
Pages (from-to)925-932
Number of pages8
JournalBritish Journal of Cancer
Volume54
Issue number6
DOIs
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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