Mitral valve surgery: Wait and see vs. early operation

Michele De Bonis, Steven F. Bolling

Research output: Contribution to journalArticlepeer-review


Mitral valve repair represents the optimal surgical treatment for severe degenerative mitral regurgitation. According to the current guidelines, mitral repair is indicated in the presence of symptoms and/or signs of left ventricular (LV) dysfunction. In asymptomatic patients with preserved LV function, surgery should be considered in the presence of atrial fibrillation (AF) and/or pulmonary hypertension. In asymptomatic patients with preserved LV function, normal pulmonary artery pressure, and no episodes of AF, surgical timing is still an object of debate. The controversial issue is whether, in those circumstances, a 'wait and see (watchful waiting)' approach should be followed or an 'early repair' policy should be preferred. Indeed, a randomized trial comparing the two strategies has never been performed. In the absence of evidence-based arguments definitely supporting any particular course of action, advantages, drawbacks, and requirements for both strategies will be discussed in this review on the basis of the most significant observational studies which have focused on this issue.

Original languageEnglish
JournalEuropean Heart Journal
Issue number1
Publication statusPublished - Jan 1 2013


  • Early repair
  • Mitral regurgitation
  • Mitral repair
  • Surgical timing
  • Wait and see

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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