Mixed acute leukemia with genotypic lineage switch: A case report

S. Ciolli, F. Leoni, R. Caporale, A. Carbone, P. Francia Di Celle, R. Foa, P. Rossi Ferrini

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Morphologically well classifiable leukemias can reveal a mixed phenotype. A case of acute myeloid leukemia (CD13, CD33, CD14, CD11b) which at presentation showed a co-expression of B-lymphoid markers (CD19, CD10, CD20), at the time of the first relapse revealed a morphologic, phenotypic and genotypic switch of the blasts to a purely lymphoid form. Analysis of the immunoglobulin (Ig) H chain locus and of the T-cell receptor (TCR) genes showed at diagnosis a germline configuration of the IgH, TCRβ and γ genes, and a deletion of the TCR δ gene at the second chromosome. At relapse, monoclonal rearrangements of the IgH, TCR γ, and TCR δ were detected. At a subsequent relapse, the blasts re-expressed myeloid morphologic features and myeloid-associated antigens, while they retained the same rearranged configuration of the IgH and TCRβ and δ genes. The TCR δ gene configuration, which links each phase of the disease, may represent an early pathogenetic event and makes the emergence of a second malignancy unlikely. Each phenotypic change occurred after anti-myeloid and anti-lymphoid oriented chemotherapy. The close correlation between the progressive acquisition of different phenotypes and the switch at the genomic level represent the peculiar features of this unusual case.

Original languageEnglish
Pages (from-to)1061-1065
Number of pages5
JournalLeukemia
Volume7
Issue number7
Publication statusPublished - 1993

Fingerprint

T-Cell Receptor Genes
Leukemia
T-Cell Antigen Receptor
Recurrence
Immunoglobulin Subunits
Phenotype
Second Primary Neoplasms
Gene Deletion
Acute Myeloid Leukemia
Chromosomes
Antigens
Drug Therapy

ASJC Scopus subject areas

  • Cancer Research
  • Hematology

Cite this

Ciolli, S., Leoni, F., Caporale, R., Carbone, A., Francia Di Celle, P., Foa, R., & Rossi Ferrini, P. (1993). Mixed acute leukemia with genotypic lineage switch: A case report. Leukemia, 7(7), 1061-1065.

Mixed acute leukemia with genotypic lineage switch : A case report. / Ciolli, S.; Leoni, F.; Caporale, R.; Carbone, A.; Francia Di Celle, P.; Foa, R.; Rossi Ferrini, P.

In: Leukemia, Vol. 7, No. 7, 1993, p. 1061-1065.

Research output: Contribution to journalArticle

Ciolli, S, Leoni, F, Caporale, R, Carbone, A, Francia Di Celle, P, Foa, R & Rossi Ferrini, P 1993, 'Mixed acute leukemia with genotypic lineage switch: A case report', Leukemia, vol. 7, no. 7, pp. 1061-1065.
Ciolli S, Leoni F, Caporale R, Carbone A, Francia Di Celle P, Foa R et al. Mixed acute leukemia with genotypic lineage switch: A case report. Leukemia. 1993;7(7):1061-1065.
Ciolli, S. ; Leoni, F. ; Caporale, R. ; Carbone, A. ; Francia Di Celle, P. ; Foa, R. ; Rossi Ferrini, P. / Mixed acute leukemia with genotypic lineage switch : A case report. In: Leukemia. 1993 ; Vol. 7, No. 7. pp. 1061-1065.
@article{2fcbac715af340d6a8554aab3fcddf16,
title = "Mixed acute leukemia with genotypic lineage switch: A case report",
abstract = "Morphologically well classifiable leukemias can reveal a mixed phenotype. A case of acute myeloid leukemia (CD13, CD33, CD14, CD11b) which at presentation showed a co-expression of B-lymphoid markers (CD19, CD10, CD20), at the time of the first relapse revealed a morphologic, phenotypic and genotypic switch of the blasts to a purely lymphoid form. Analysis of the immunoglobulin (Ig) H chain locus and of the T-cell receptor (TCR) genes showed at diagnosis a germline configuration of the IgH, TCRβ and γ genes, and a deletion of the TCR δ gene at the second chromosome. At relapse, monoclonal rearrangements of the IgH, TCR γ, and TCR δ were detected. At a subsequent relapse, the blasts re-expressed myeloid morphologic features and myeloid-associated antigens, while they retained the same rearranged configuration of the IgH and TCRβ and δ genes. The TCR δ gene configuration, which links each phase of the disease, may represent an early pathogenetic event and makes the emergence of a second malignancy unlikely. Each phenotypic change occurred after anti-myeloid and anti-lymphoid oriented chemotherapy. The close correlation between the progressive acquisition of different phenotypes and the switch at the genomic level represent the peculiar features of this unusual case.",
author = "S. Ciolli and F. Leoni and R. Caporale and A. Carbone and {Francia Di Celle}, P. and R. Foa and {Rossi Ferrini}, P.",
year = "1993",
language = "English",
volume = "7",
pages = "1061--1065",
journal = "Leukemia",
issn = "0887-6924",
publisher = "Nature Publishing Group",
number = "7",

}

TY - JOUR

T1 - Mixed acute leukemia with genotypic lineage switch

T2 - A case report

AU - Ciolli, S.

AU - Leoni, F.

AU - Caporale, R.

AU - Carbone, A.

AU - Francia Di Celle, P.

AU - Foa, R.

AU - Rossi Ferrini, P.

PY - 1993

Y1 - 1993

N2 - Morphologically well classifiable leukemias can reveal a mixed phenotype. A case of acute myeloid leukemia (CD13, CD33, CD14, CD11b) which at presentation showed a co-expression of B-lymphoid markers (CD19, CD10, CD20), at the time of the first relapse revealed a morphologic, phenotypic and genotypic switch of the blasts to a purely lymphoid form. Analysis of the immunoglobulin (Ig) H chain locus and of the T-cell receptor (TCR) genes showed at diagnosis a germline configuration of the IgH, TCRβ and γ genes, and a deletion of the TCR δ gene at the second chromosome. At relapse, monoclonal rearrangements of the IgH, TCR γ, and TCR δ were detected. At a subsequent relapse, the blasts re-expressed myeloid morphologic features and myeloid-associated antigens, while they retained the same rearranged configuration of the IgH and TCRβ and δ genes. The TCR δ gene configuration, which links each phase of the disease, may represent an early pathogenetic event and makes the emergence of a second malignancy unlikely. Each phenotypic change occurred after anti-myeloid and anti-lymphoid oriented chemotherapy. The close correlation between the progressive acquisition of different phenotypes and the switch at the genomic level represent the peculiar features of this unusual case.

AB - Morphologically well classifiable leukemias can reveal a mixed phenotype. A case of acute myeloid leukemia (CD13, CD33, CD14, CD11b) which at presentation showed a co-expression of B-lymphoid markers (CD19, CD10, CD20), at the time of the first relapse revealed a morphologic, phenotypic and genotypic switch of the blasts to a purely lymphoid form. Analysis of the immunoglobulin (Ig) H chain locus and of the T-cell receptor (TCR) genes showed at diagnosis a germline configuration of the IgH, TCRβ and γ genes, and a deletion of the TCR δ gene at the second chromosome. At relapse, monoclonal rearrangements of the IgH, TCR γ, and TCR δ were detected. At a subsequent relapse, the blasts re-expressed myeloid morphologic features and myeloid-associated antigens, while they retained the same rearranged configuration of the IgH and TCRβ and δ genes. The TCR δ gene configuration, which links each phase of the disease, may represent an early pathogenetic event and makes the emergence of a second malignancy unlikely. Each phenotypic change occurred after anti-myeloid and anti-lymphoid oriented chemotherapy. The close correlation between the progressive acquisition of different phenotypes and the switch at the genomic level represent the peculiar features of this unusual case.

UR - http://www.scopus.com/inward/record.url?scp=0027204060&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027204060&partnerID=8YFLogxK

M3 - Article

C2 - 8321022

AN - SCOPUS:0027204060

VL - 7

SP - 1061

EP - 1065

JO - Leukemia

JF - Leukemia

SN - 0887-6924

IS - 7

ER -