Abstract
Mixed connective tissue disease (MCTD) is a rheumatological disease which has to be distinguished from other entities causing inflammatory myopathy. The usual clinical presentation of inflammatory myopathy associated with connective tissue disease is not different from isolated polymyositis or dermatomyositis, i.e., subacute onset of proximal weakness affecting both upper and lower girdle with high serum CK level. Here we report a patient with MCTD/myositis overlap syndrome displaying an uncommon clinical presentation and a distribution of muscle weakness involving facial, neck and arm muscles with sparing of lower limbs. We also describe the scarcity of muscle regeneration signs on the muscle biopsy with complete absence of alkaline phosphatase positivity in the endomysial and permysial connective tissue as a novel finding of this condition.
| Original language | English |
|---|---|
| Pages (from-to) | 171-174 |
| Number of pages | 4 |
| Journal | Neurological Sciences |
| Volume | 32 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Feb 2011 |
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Keywords
- Alkaline phosphatase staining
- Inflammatory myopathy
- Mixed connective tissue disease
- Muscle regeneration
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health
- Dermatology
Cite this
Mixed connective tissue disease presenting as a peculiar myositis with poor muscle regeneration. / Tasca, Giorgio; Mirabella, Massimiliano; Berrettini, Alfredo; Monforte, Mauro; Tonali, Pietro Attilio; Ricci, Enzo.
In: Neurological Sciences, Vol. 32, No. 1, 02.2011, p. 171-174.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mixed connective tissue disease presenting as a peculiar myositis with poor muscle regeneration
AU - Tasca, Giorgio
AU - Mirabella, Massimiliano
AU - Berrettini, Alfredo
AU - Monforte, Mauro
AU - Tonali, Pietro Attilio
AU - Ricci, Enzo
PY - 2011/2
Y1 - 2011/2
N2 - Mixed connective tissue disease (MCTD) is a rheumatological disease which has to be distinguished from other entities causing inflammatory myopathy. The usual clinical presentation of inflammatory myopathy associated with connective tissue disease is not different from isolated polymyositis or dermatomyositis, i.e., subacute onset of proximal weakness affecting both upper and lower girdle with high serum CK level. Here we report a patient with MCTD/myositis overlap syndrome displaying an uncommon clinical presentation and a distribution of muscle weakness involving facial, neck and arm muscles with sparing of lower limbs. We also describe the scarcity of muscle regeneration signs on the muscle biopsy with complete absence of alkaline phosphatase positivity in the endomysial and permysial connective tissue as a novel finding of this condition.
AB - Mixed connective tissue disease (MCTD) is a rheumatological disease which has to be distinguished from other entities causing inflammatory myopathy. The usual clinical presentation of inflammatory myopathy associated with connective tissue disease is not different from isolated polymyositis or dermatomyositis, i.e., subacute onset of proximal weakness affecting both upper and lower girdle with high serum CK level. Here we report a patient with MCTD/myositis overlap syndrome displaying an uncommon clinical presentation and a distribution of muscle weakness involving facial, neck and arm muscles with sparing of lower limbs. We also describe the scarcity of muscle regeneration signs on the muscle biopsy with complete absence of alkaline phosphatase positivity in the endomysial and permysial connective tissue as a novel finding of this condition.
KW - Alkaline phosphatase staining
KW - Inflammatory myopathy
KW - Mixed connective tissue disease
KW - Muscle regeneration
UR - http://www.scopus.com/inward/record.url?scp=79551596636&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79551596636&partnerID=8YFLogxK
U2 - 10.1007/s10072-010-0423-1
DO - 10.1007/s10072-010-0423-1
M3 - Article
C2 - 20890626
AN - SCOPUS:79551596636
VL - 32
SP - 171
EP - 174
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 1
ER -