Mixed cryoglobulinemia secondary to visceral leishmaniasis

Milvia Casato, Francesco G. De Rosa, Leopoldo P. Pucillo, Ignazio Ilardi, Bruno Di Vico, Lelio R. Zorzin, Maria Laura Sorgi, Pamela Fiaschetti, Rossella Coviello, Bruno Laganà, Massimo Fiorilli

Research output: Contribution to journalArticlepeer-review


We describe a case of type II mixed cryoglobulinemia, with monoclonal IgMκ rheumatoid factor, associated with visceral leishmaniasis caused by Leishmania infantum. Involvement of Leishmania antigen(s) in the formation of cryoprecipitable immune complexes was suggested by the fact that cryoglobulinemic vasculitis subsided after antiparasite therapy and that anti-Leishmania antibodies, as well as rheumatoid factor, were enriched in the cryoprecipitate. We observed 2 additional patients with visceral leishmaniasis and cryoglobulinemic vasculitis. All 3 patients had seemingly contracted leishmaniasis in Italy, were hepatitis C virus negative, and were initially diagnosed as having autoimmune disorders. These findings indicate that Leishmania can be an etiologic agent of type II mixed cryoglobulinemia. This parasitosis should be taken into consideration in the differential diagnosis of vasculitides in endemic areas.

Original languageEnglish
Pages (from-to)2007-2011
Number of pages5
JournalArthritis and Rheumatism
Issue number9
Publication statusPublished - Sep 1999

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

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