Mixed-lineage leukemias and phenotypic shifts occurring in relapsed cases of acute T lymphoblastic lymphomas

D. Delia, N. Polli, M. G. Borrello, E. Fontanella, D. Biassoni, F. Morandi, G. Cattoretti, A. Orazi, G. Della Porta

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Abstract

Specimens from 19 patients with NHL were also phenotyped at the onset of the disease; among them, 9 were studied in the relapse phase. The analysis was carried out with monoclonal antibodies directed against T and myeloid cells; at diagnosis, all cases presented an immature thymic phenotype. When analyzed at relapse, phenotypic changes were observed: intra-lineage dedifferentiations (6 cases); mixed-lineage lymphoid and myeloid (2 cases), and pure myeloid relapses (1 case). The molecular analysis of the TCR-genes configuration showed a germ-line pattern at onset and relapse in Case 9 and a modification of the rearrangement patterns during the evolution of the disease in Case 6. These data point out that the relapse is often accompanied by intralineage modifications resembling dedifferentiation and, more rarely by a myeloid switch. The phenotypic follow-up of these patients may be important to the implementation of chemotherapeutic protocols that are more adequate for the biological evolution of the disease.

Original languageEnglish
JournalLeukemia
Volume2
Issue number12 SUPPL.
Publication statusPublished - 1988

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ASJC Scopus subject areas

  • Cancer Research
  • Hematology

Cite this

Delia, D., Polli, N., Borrello, M. G., Fontanella, E., Biassoni, D., Morandi, F., Cattoretti, G., Orazi, A., & Della Porta, G. (1988). Mixed-lineage leukemias and phenotypic shifts occurring in relapsed cases of acute T lymphoblastic lymphomas. Leukemia, 2(12 SUPPL.).