Abstract
The morphological, immunohistochemical, and molecular biological features of a case of giant cell tumor of the pancreas are described. This neoplasm showed mononuclear and multinucleated tumor giant cells as well as numerous osteoclast-like cells with multiple foci of osteoid-osseous metaplasia. The pleomorphic and osteoclastic giant cells displayed extensive homologies in their immunohistochemical profiles. Neither the pleomorphic nor osteoclast-like portion of the tumor showed neither c-Ki-ras nor p53 mutation and did not express the mutated p53 protein. The results suggest that the pleomorphic and osteoclast-like components are histogenetically related and that this rare neoplasm originates from a precursor cell capable of differentiating along divergent cell type.
Original language | English |
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Pages (from-to) | 169-175 |
Number of pages | 7 |
Journal | International Journal of Pancreatology |
Volume | 18 |
Issue number | 2 |
DOIs | |
Publication status | Published - Oct 1995 |
Keywords
- c-Ki-ras
- Exocrine pancreas
- histogenesis
- immunohistochemistry
- osteoclast-like cell tumor
- p53
- pleomorphic giant cell carcinoma
ASJC Scopus subject areas
- Oncology
- Gastroenterology
- Endocrinology