Mixed pleomorphic-osteoclast-like tumor of the pancreas - Light microscopical, immunohistochemical, and molecular biological studies

Beatrice Gatteschi, Sebastiano Saccomanno, Francesco Griffanti Bartoli, Sandra Salvi, Guozhen Liu, Vittorio Pugliese

Research output: Contribution to journalArticle

Abstract

The morphological, immunohistochemical, and molecular biological features of a case of giant cell tumor of the pancreas are described. This neoplasm showed mononuclear and multinucleated tumor giant cells as well as numerous osteoclast-like cells with multiple foci of osteoid-osseous metaplasia. The pleomorphic and osteoclastic giant cells displayed extensive homologies in their immunohistochemical profiles. Neither the pleomorphic nor osteoclast-like portion of the tumor showed neither c-Ki-ras nor p53 mutation and did not express the mutated p53 protein. The results suggest that the pleomorphic and osteoclast-like components are histogenetically related and that this rare neoplasm originates from a precursor cell capable of differentiating along divergent cell type.

Original languageEnglish
Pages (from-to)169-175
Number of pages7
JournalInternational Journal of Pancreatology
Volume18
Issue number2
DOIs
Publication statusPublished - Oct 1995

Keywords

  • c-Ki-ras
  • Exocrine pancreas
  • histogenesis
  • immunohistochemistry
  • osteoclast-like cell tumor
  • p53
  • pleomorphic giant cell carcinoma

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology
  • Endocrinology

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