Mixing and modes of mass transfer in the third cerebral ventricle: A computational analysis

Vartan Kurtcuoglu, Michaela Soellinger, Paul Summers, Dimos Poulikakos, Peter Boesiger

Research output: Contribution to journalArticlepeer-review


Anatomic, velocimetric, and brain motion MRI scans were combined with a computational fluid dynamics model to investigate cerebrospinal fluid (CSF) mixing in the third cerebral ventricle of a healthy male adult. It was found that advection dominates over diffusion in most of the third ventricle. Three zones where diffusion plays an important role in the mixing process were identified. One of these zones, consisting of recessus infundibulus, recessus opticus and the adjacent regions up to commissura anterior, is likely to exist in the general population. We hypothesize that this zone may act as a buffer to flatten concentration peaks of pituitary gland hormones released into the CSF of the third ventricle. We further hypothesize that this zone may facilitate the communication between hypothalamus and the pituitary gland through the third ventricle cerebrospinal fluid by prolonging residence times of the communicated hormones.

Original languageEnglish
Pages (from-to)695-702
Number of pages8
JournalJournal of Biomechanical Engineering
Issue number5
Publication statusPublished - Oct 2007

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biophysics


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