Abstract
The occurrence of MLL gene rearrangement in acute megakaryoblastic leukemia (AML-M7, acute myeloid leukemia, French-American-British type M7) is very rare and limited to pediatric age: in particular, MLL-MLLT10 fusion, previously reported as characteristic of monocytic leukemia, has been reported in only one case of pediatric megakaryoblastic leukemia. We describe the second case with this association in light of the few reported cases of AML-M7 with MLL and/or 11q23 involvement.
| Original language | English |
|---|---|
| Pages (from-to) | 1223-1226 |
| Number of pages | 4 |
| Journal | Leukemia Research |
| Volume | 29 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 2005 |
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Keywords
- Acute megakaryoblastic leukemia
- FISH
- M-FISH
- MLL-MLLT10 fusion gene
ASJC Scopus subject areas
- Cancer Research
- Hematology
- Oncology
Cite this
MLL-MLLT10 fusion gene in pediatric acute megakaryoblastic leukemia. / Morerio, Cristina; Rapella, Annamaria; Tassano, Elisa; Rosanda, Cristina; Panarello, Claudio.
In: Leukemia Research, Vol. 29, No. 10, 10.2005, p. 1223-1226.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - MLL-MLLT10 fusion gene in pediatric acute megakaryoblastic leukemia
AU - Morerio, Cristina
AU - Rapella, Annamaria
AU - Tassano, Elisa
AU - Rosanda, Cristina
AU - Panarello, Claudio
PY - 2005/10
Y1 - 2005/10
N2 - The occurrence of MLL gene rearrangement in acute megakaryoblastic leukemia (AML-M7, acute myeloid leukemia, French-American-British type M7) is very rare and limited to pediatric age: in particular, MLL-MLLT10 fusion, previously reported as characteristic of monocytic leukemia, has been reported in only one case of pediatric megakaryoblastic leukemia. We describe the second case with this association in light of the few reported cases of AML-M7 with MLL and/or 11q23 involvement.
AB - The occurrence of MLL gene rearrangement in acute megakaryoblastic leukemia (AML-M7, acute myeloid leukemia, French-American-British type M7) is very rare and limited to pediatric age: in particular, MLL-MLLT10 fusion, previously reported as characteristic of monocytic leukemia, has been reported in only one case of pediatric megakaryoblastic leukemia. We describe the second case with this association in light of the few reported cases of AML-M7 with MLL and/or 11q23 involvement.
KW - Acute megakaryoblastic leukemia
KW - FISH
KW - M-FISH
KW - MLL-MLLT10 fusion gene
UR - http://www.scopus.com/inward/record.url?scp=23844445762&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=23844445762&partnerID=8YFLogxK
U2 - 10.1016/j.leukres.2005.03.008
DO - 10.1016/j.leukres.2005.03.008
M3 - Article
C2 - 16111539
AN - SCOPUS:23844445762
VL - 29
SP - 1223
EP - 1226
JO - Leukemia Research
JF - Leukemia Research
SN - 0145-2126
IS - 10
ER -