MLL-MLLT10 fusion gene in pediatric acute megakaryoblastic leukemia

Cristina Morerio, Annamaria Rapella, Elisa Tassano, Cristina Rosanda, Claudio Panarello

Research output: Contribution to journalArticlepeer-review

Abstract

The occurrence of MLL gene rearrangement in acute megakaryoblastic leukemia (AML-M7, acute myeloid leukemia, French-American-British type M7) is very rare and limited to pediatric age: in particular, MLL-MLLT10 fusion, previously reported as characteristic of monocytic leukemia, has been reported in only one case of pediatric megakaryoblastic leukemia. We describe the second case with this association in light of the few reported cases of AML-M7 with MLL and/or 11q23 involvement.

Original languageEnglish
Pages (from-to)1223-1226
Number of pages4
JournalLeukemia Research
Volume29
Issue number10
DOIs
Publication statusPublished - Oct 2005

Keywords

  • Acute megakaryoblastic leukemia
  • FISH
  • M-FISH
  • MLL-MLLT10 fusion gene

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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