MLL-MLLT10 fusion gene in pediatric acute megakaryoblastic leukemia

Cristina Morerio; Annamaria Rapella; Elisa Tassano; Cristina Rosanda; Claudio Panarello

doi:10.1016/j.leukres.2005.03.008

MLL-MLLT10 fusion gene in pediatric acute megakaryoblastic leukemia

Cristina Morerio, Annamaria Rapella, Elisa Tassano, Cristina Rosanda, Claudio Panarello

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

The occurrence of MLL gene rearrangement in acute megakaryoblastic leukemia (AML-M7, acute myeloid leukemia, French-American-British type M7) is very rare and limited to pediatric age: in particular, MLL-MLLT10 fusion, previously reported as characteristic of monocytic leukemia, has been reported in only one case of pediatric megakaryoblastic leukemia. We describe the second case with this association in light of the few reported cases of AML-M7 with MLL and/or 11q23 involvement.

Original language	English
Pages (from-to)	1223-1226
Number of pages	4
Journal	Leukemia Research
Volume	29
Issue number	10
DOIs	https://doi.org/10.1016/j.leukres.2005.03.008
Publication status	Published - Oct 2005

Keywords

Acute megakaryoblastic leukemia
FISH
M-FISH
MLL-MLLT10 fusion gene

ASJC Scopus subject areas

Cancer Research
Hematology
Oncology

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title = "MLL-MLLT10 fusion gene in pediatric acute megakaryoblastic leukemia",

abstract = "The occurrence of MLL gene rearrangement in acute megakaryoblastic leukemia (AML-M7, acute myeloid leukemia, French-American-British type M7) is very rare and limited to pediatric age: in particular, MLL-MLLT10 fusion, previously reported as characteristic of monocytic leukemia, has been reported in only one case of pediatric megakaryoblastic leukemia. We describe the second case with this association in light of the few reported cases of AML-M7 with MLL and/or 11q23 involvement.",

keywords = "Acute megakaryoblastic leukemia, FISH, M-FISH, MLL-MLLT10 fusion gene",

author = "Cristina Morerio and Annamaria Rapella and Elisa Tassano and Cristina Rosanda and Claudio Panarello",

year = "2005",

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language = "English",

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T1 - MLL-MLLT10 fusion gene in pediatric acute megakaryoblastic leukemia

AU - Morerio, Cristina

AU - Rapella, Annamaria

AU - Tassano, Elisa

AU - Rosanda, Cristina

AU - Panarello, Claudio

PY - 2005/10

Y1 - 2005/10

N2 - The occurrence of MLL gene rearrangement in acute megakaryoblastic leukemia (AML-M7, acute myeloid leukemia, French-American-British type M7) is very rare and limited to pediatric age: in particular, MLL-MLLT10 fusion, previously reported as characteristic of monocytic leukemia, has been reported in only one case of pediatric megakaryoblastic leukemia. We describe the second case with this association in light of the few reported cases of AML-M7 with MLL and/or 11q23 involvement.

AB - The occurrence of MLL gene rearrangement in acute megakaryoblastic leukemia (AML-M7, acute myeloid leukemia, French-American-British type M7) is very rare and limited to pediatric age: in particular, MLL-MLLT10 fusion, previously reported as characteristic of monocytic leukemia, has been reported in only one case of pediatric megakaryoblastic leukemia. We describe the second case with this association in light of the few reported cases of AML-M7 with MLL and/or 11q23 involvement.

KW - Acute megakaryoblastic leukemia

KW - FISH

KW - M-FISH

KW - MLL-MLLT10 fusion gene

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