MLL-MLLT10 fusion in acute monoblastic leukemia: Variant complex rearrangements and 11q proximal breakpoint heterogeneity

Cristina Morerio, Annamaria Rapella, Cristina Rosanda, Edoardo Lanino, Luca Lo Nigro, Andrea Di Cataldo, Emanuela Maserati, Francesco Pasquali, Claudio Panarello

Research output: Contribution to journalArticle

Abstract

Cytogenetic studies of acute monoblastic leukemia cases presenting MLL-MLLT10 (alias MLL-AF10) fusion show a broad heterogeneity of chromosomal breakpoints. We present two new pediatric cases (French-American-British type M5) with MLL-MLLT10 fusion, which we studied with fluorescence in situ hybridization. In both we detected a paracentric inversion of the 11q region that translocated onto chromosome 10p12; one case displayed a variant complex pattern. We review the cytogenetic molecular data concerning the proximal inversion breakpoint of 11q and confirm its heterogeneity.

Original languageEnglish
Pages (from-to)108-112
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume152
Issue number2
DOIs
Publication statusPublished - Jul 15 2004

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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