MLR-specific suppressor T lymphocytes in man. II. Functional and membrane characteristics of a specific MLR suppressor subpopulation

G. Fabio, R. Scorza-Smeraldi, P. Bonara, M. G. Sabbadini Villa, M. Vanoli, F. Calabi, C. Zanussi

Research output: Contribution to journalArticlepeer-review

Abstract

Human MLR-specific suppressor T lymphocytes were induced by in vitro cultivation of human peripheral T lymphocytes in the presence of soluble HLA-DR alloantigens isolated from normal serum. The suppression is specific in that responder cells autologous to the suppressor cells respond to allogeneic stimulating cells that express the same HLA-DR specificity as that recovered from serum and used to induce the suppressor cells. This antigen-specific suppressor T cell population could be divided into suppressor and non-suppressor subpopulations as a function of adherence to a 6MB Sepharose immunoadsorbent coated with the inducing HLA-DR soluble antigen. As a consequence of activation by soluble DR antigen, the suppressor T lymphocyte population as well as the column-enriched suppressor subpopulation express new membrane specificities that can be recognized by anti-sera from pluriparous women. The specificities that are recognized are not found on autologous, unstimulated B and T cells, nor do they appear to recognize conventional HLA-A,B,C or DR determinants.

Original languageEnglish
Pages (from-to)2458-2462
Number of pages5
JournalJournal of Immunology
Volume129
Issue number6
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Immunology

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