MLR-specific suppressor T lymphocytes in man. II. Functional and membrane characteristics of a specific MLR suppressor subpopulation

G. Fabio, R. Scorza-Smeraldi, P. Bonara, M. G. Sabbadini Villa, M. Vanoli, F. Calabi, C. Zanussi

Research output: Contribution to journalArticle

Abstract

Human MLR-specific suppressor T lymphocytes were induced by in vitro cultivation of human peripheral T lymphocytes in the presence of soluble HLA-DR alloantigens isolated from normal serum. The suppression is specific in that responder cells autologous to the suppressor cells respond to allogeneic stimulating cells that express the same HLA-DR specificity as that recovered from serum and used to induce the suppressor cells. This antigen-specific suppressor T cell population could be divided into suppressor and non-suppressor subpopulations as a function of adherence to a 6MB Sepharose immunoadsorbent coated with the inducing HLA-DR soluble antigen. As a consequence of activation by soluble DR antigen, the suppressor T lymphocyte population as well as the column-enriched suppressor subpopulation express new membrane specificities that can be recognized by anti-sera from pluriparous women. The specificities that are recognized are not found on autologous, unstimulated B and T cells, nor do they appear to recognize conventional HLA-A,B,C or DR determinants.

Original languageEnglish
Pages (from-to)2458-2462
Number of pages5
JournalJournal of Immunology
Volume129
Issue number6
Publication statusPublished - 1982

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T-Lymphocytes
HLA-DR Antigens
Membranes
Serum
Antigens
Immunosorbents
HLA-A Antigens
HLA-B Antigens
Isoantigens
Population
B-Lymphocytes

ASJC Scopus subject areas

  • Immunology

Cite this

Fabio, G., Scorza-Smeraldi, R., Bonara, P., Sabbadini Villa, M. G., Vanoli, M., Calabi, F., & Zanussi, C. (1982). MLR-specific suppressor T lymphocytes in man. II. Functional and membrane characteristics of a specific MLR suppressor subpopulation. Journal of Immunology, 129(6), 2458-2462.

MLR-specific suppressor T lymphocytes in man. II. Functional and membrane characteristics of a specific MLR suppressor subpopulation. / Fabio, G.; Scorza-Smeraldi, R.; Bonara, P.; Sabbadini Villa, M. G.; Vanoli, M.; Calabi, F.; Zanussi, C.

In: Journal of Immunology, Vol. 129, No. 6, 1982, p. 2458-2462.

Research output: Contribution to journalArticle

Fabio, G, Scorza-Smeraldi, R, Bonara, P, Sabbadini Villa, MG, Vanoli, M, Calabi, F & Zanussi, C 1982, 'MLR-specific suppressor T lymphocytes in man. II. Functional and membrane characteristics of a specific MLR suppressor subpopulation', Journal of Immunology, vol. 129, no. 6, pp. 2458-2462.
Fabio G, Scorza-Smeraldi R, Bonara P, Sabbadini Villa MG, Vanoli M, Calabi F et al. MLR-specific suppressor T lymphocytes in man. II. Functional and membrane characteristics of a specific MLR suppressor subpopulation. Journal of Immunology. 1982;129(6):2458-2462.
Fabio, G. ; Scorza-Smeraldi, R. ; Bonara, P. ; Sabbadini Villa, M. G. ; Vanoli, M. ; Calabi, F. ; Zanussi, C. / MLR-specific suppressor T lymphocytes in man. II. Functional and membrane characteristics of a specific MLR suppressor subpopulation. In: Journal of Immunology. 1982 ; Vol. 129, No. 6. pp. 2458-2462.
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