MLR3 molecule is an activation antigen shared by human B, T lymphocytes and T cell precursors

A. Risso, M. E. Cosulich, A. Rubartelli, M. R. Mazza, A. Bargellesi

Research output: Contribution to journalArticle

Abstract

MLR3 molecule is a membrane glycoprotein (mol. mass range 28-34 kDa) present on activated, but not resting human peripheral T cells, B cells and thymocytes. Its kinetics of appearance on the cell surface (3 h after the addition of the inductive signal to the cells) suggests that it is an early activation antigen. The proliferative response of cultured T and B lymphocytes and thymocytes to different activation signals is inhibited by the addition of MLR3 monoclonal antibody. Moreover the antibody in combination with non-mitogenic doses of phorbol myristate acetate leads to proliferation of thymocytes and resting B and T lymphocytes. In the latter, synthesis of interleukin 2 is also induced. Biochemical analysis of MLR3 antigen indicates that it is a phosphorylated protein with N-linked sugar moieties. Together these data suggest a role for MLR3 antigen in the signal transduction process during activation, both for mature lymphocytes and for T cell precursors.

Original languageEnglish
Pages (from-to)323-328
Number of pages6
JournalEuropean Journal of Immunology
Volume19
Issue number2
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Immunology

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    Risso, A., Cosulich, M. E., Rubartelli, A., Mazza, M. R., & Bargellesi, A. (1989). MLR3 molecule is an activation antigen shared by human B, T lymphocytes and T cell precursors. European Journal of Immunology, 19(2), 323-328.