MMP-13 expression in keratocyst odontogenic tumour associated with NBCCS and sporadic keratocysts

R. Leonardi, J. Matthews, R. Caltabiano, M. Greco, C. Lombardo, C. Loreto, A. Santarelli, L. Lo Muzio

Research output: Contribution to journalArticlepeer-review


To investigate the matrix metalloproteinase (MMP)-13 expression in associated and non-nevoid basal cell carcinoma syndrome (NBCCS) Odontogenic Keratocysts (OCKs) in order to contribute to a better understanding of the differences in the growth pattern between them.Materials and methods: Thirty-nine paraffin-embedded blocks of OCKs, 26 sporadic OCKs and 11 NBCCS-associated KCOTs were studied by immunohistochemistry to evaluate MMP-13 expression both in epithelial and stromal layers. A semi-quantitative scale was used to evaluate immunostaining. Obtained data were compared between the two groups, using Fischer's exact test and the chi-square test.Results: Only 13 of 26 sporadic OCKs showed a positive immunostaining, whilst 11 KCOTs resulted in positive labelling for MMP-13 expression. Moreover, syndromic cysts displayed a more intense and diffuse MMP-13 labelling of the stromal tissue. Instead, in non-syndromic forms, the staining pattern of MMP-13 in stromal tissue was completely absent. Fisher's exact test showed a statistically significant greater prevalence of KCOTs-immunolabelled cysts with respect to sporadic OCKs.Conclusions: Results from this study point out that the biological behaviour of these cysts could be related not only to the epithelial layer but also to stromal tissue in that... MMP-13 overexpression in stromal tissue of NBCCS-associated KCOTs could clarify the higher aggressiveness of these cysts.

Original languageEnglish
Pages (from-to)795-800
Number of pages6
JournalOral Diseases
Issue number8
Publication statusPublished - Nov 2010


  • Gorlin-Gotz syndrome
  • MMP13
  • Odontogenic keratocysts

ASJC Scopus subject areas

  • Dentistry(all)
  • Otorhinolaryngology


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