MMP-9 microsatellite polymorphism and multiple sclerosis

Nicola Fiotti, Robert Zivadinov, Nicola Altamura, Davide Nasuelli, Alessio Bratina, Maria Antonietta Tommasi, Antonio Bosco, Laura Locatelli, Attilio Grop, Giuseppe Cazzato, Gianfranco Guarnieri, Carlo Giansante, Marino Zorzon

Research output: Contribution to journalArticlepeer-review

Abstract

A polymorphism (PM) in the microsatellite of the promoter region of matrix metalloproteinase 9 (MMP-9), modulating its expression, could play a role in susceptibility to multiple sclerosis (MS). MMP-9 PM was determined in 95 patients with MS (MS Group) and 95 age- and sex-matched controls (Control Group). Comparison of allelic frequencies showed that a higher number of CA repeats characterized the MS group (P22 CA repeats (33±10 vs. 28±10, P=0.027). No differences were found in the main MRI parameters.

Original languageEnglish
Pages (from-to)147-153
Number of pages7
JournalJournal of Neuroimmunology
Volume152
Issue number1-2
DOIs
Publication statusPublished - Jul 2004

Keywords

  • MMP-9
  • MRI
  • Multiple sclerosis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

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