TY - JOUR
T1 - MMP-9 microsatellite polymorphism and multiple sclerosis
AU - Fiotti, Nicola
AU - Zivadinov, Robert
AU - Altamura, Nicola
AU - Nasuelli, Davide
AU - Bratina, Alessio
AU - Tommasi, Maria Antonietta
AU - Bosco, Antonio
AU - Locatelli, Laura
AU - Grop, Attilio
AU - Cazzato, Giuseppe
AU - Guarnieri, Gianfranco
AU - Giansante, Carlo
AU - Zorzon, Marino
PY - 2004/7
Y1 - 2004/7
N2 - A polymorphism (PM) in the microsatellite of the promoter region of matrix metalloproteinase 9 (MMP-9), modulating its expression, could play a role in susceptibility to multiple sclerosis (MS). MMP-9 PM was determined in 95 patients with MS (MS Group) and 95 age- and sex-matched controls (Control Group). Comparison of allelic frequencies showed that a higher number of CA repeats characterized the MS group (P22 CA repeats (33±10 vs. 28±10, P=0.027). No differences were found in the main MRI parameters.
AB - A polymorphism (PM) in the microsatellite of the promoter region of matrix metalloproteinase 9 (MMP-9), modulating its expression, could play a role in susceptibility to multiple sclerosis (MS). MMP-9 PM was determined in 95 patients with MS (MS Group) and 95 age- and sex-matched controls (Control Group). Comparison of allelic frequencies showed that a higher number of CA repeats characterized the MS group (P22 CA repeats (33±10 vs. 28±10, P=0.027). No differences were found in the main MRI parameters.
KW - MMP-9
KW - MRI
KW - Multiple sclerosis
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U2 - 10.1016/j.jneuroim.2004.03.009
DO - 10.1016/j.jneuroim.2004.03.009
M3 - Article
C2 - 15223247
AN - SCOPUS:3042610060
VL - 152
SP - 147
EP - 153
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -