MMP-9 microsatellite polymorphism and multiple sclerosis

Nicola Fiotti; Robert Zivadinov; Nicola Altamura; Davide Nasuelli; Alessio Bratina; Maria Antonietta Tommasi; Antonio Bosco; Laura Locatelli; Attilio Grop; Giuseppe Cazzato; Gianfranco Guarnieri; Carlo Giansante; Marino Zorzon

doi:10.1016/j.jneuroim.2004.03.009

MMP-9 microsatellite polymorphism and multiple sclerosis

Nicola Fiotti, Robert Zivadinov, Nicola Altamura, Davide Nasuelli, Alessio Bratina, Maria Antonietta Tommasi, Antonio Bosco, Laura Locatelli, Attilio Grop, Giuseppe Cazzato, Gianfranco Guarnieri, Carlo Giansante, Marino Zorzon

Istituti Clinici Scientifici Maugeri Spa – Società Benefit

Research output: Contribution to journal › Article › peer-review

Abstract

A polymorphism (PM) in the microsatellite of the promoter region of matrix metalloproteinase 9 (MMP-9), modulating its expression, could play a role in susceptibility to multiple sclerosis (MS). MMP-9 PM was determined in 95 patients with MS (MS Group) and 95 age- and sex-matched controls (Control Group). Comparison of allelic frequencies showed that a higher number of CA repeats characterized the MS group (P22 CA repeats (33±10 vs. 28±10, P=0.027). No differences were found in the main MRI parameters.

Original language	English
Pages (from-to)	147-153
Number of pages	7
Journal	Journal of Neuroimmunology
Volume	152
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2004.03.009
Publication status	Published - Jul 2004

Keywords

MMP-9
MRI
Multiple sclerosis

ASJC Scopus subject areas

Immunology
Immunology and Allergy
Clinical Neurology
Neurology

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10.1016/j.jneuroim.2004.03.009

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MMP-9 microsatellite polymorphism and multiple sclerosis. / Fiotti, Nicola; Zivadinov, Robert; Altamura, Nicola; Nasuelli, Davide; Bratina, Alessio; Tommasi, Maria Antonietta; Bosco, Antonio; Locatelli, Laura; Grop, Attilio; Cazzato, Giuseppe; Guarnieri, Gianfranco; Giansante, Carlo; Zorzon, Marino.

In: Journal of Neuroimmunology, Vol. 152, No. 1-2, 07.2004, p. 147-153.

Research output: Contribution to journal › Article › peer-review

Fiotti, Nicola ; Zivadinov, Robert ; Altamura, Nicola ; Nasuelli, Davide ; Bratina, Alessio ; Tommasi, Maria Antonietta ; Bosco, Antonio ; Locatelli, Laura ; Grop, Attilio ; Cazzato, Giuseppe ; Guarnieri, Gianfranco ; Giansante, Carlo ; Zorzon, Marino. / MMP-9 microsatellite polymorphism and multiple sclerosis. In: Journal of Neuroimmunology. 2004 ; Vol. 152, No. 1-2. pp. 147-153.

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abstract = "A polymorphism (PM) in the microsatellite of the promoter region of matrix metalloproteinase 9 (MMP-9), modulating its expression, could play a role in susceptibility to multiple sclerosis (MS). MMP-9 PM was determined in 95 patients with MS (MS Group) and 95 age- and sex-matched controls (Control Group). Comparison of allelic frequencies showed that a higher number of CA repeats characterized the MS group (P22 CA repeats (33±10 vs. 28±10, P=0.027). No differences were found in the main MRI parameters.",

keywords = "MMP-9, MRI, Multiple sclerosis",

author = "Nicola Fiotti and Robert Zivadinov and Nicola Altamura and Davide Nasuelli and Alessio Bratina and Tommasi, {Maria Antonietta} and Antonio Bosco and Laura Locatelli and Attilio Grop and Giuseppe Cazzato and Gianfranco Guarnieri and Carlo Giansante and Marino Zorzon",

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AU - Fiotti, Nicola

AU - Zivadinov, Robert

AU - Altamura, Nicola

AU - Nasuelli, Davide

AU - Bratina, Alessio

AU - Tommasi, Maria Antonietta

AU - Bosco, Antonio

AU - Locatelli, Laura

AU - Grop, Attilio

AU - Cazzato, Giuseppe

AU - Guarnieri, Gianfranco

AU - Giansante, Carlo

AU - Zorzon, Marino

PY - 2004/7

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N2 - A polymorphism (PM) in the microsatellite of the promoter region of matrix metalloproteinase 9 (MMP-9), modulating its expression, could play a role in susceptibility to multiple sclerosis (MS). MMP-9 PM was determined in 95 patients with MS (MS Group) and 95 age- and sex-matched controls (Control Group). Comparison of allelic frequencies showed that a higher number of CA repeats characterized the MS group (P22 CA repeats (33±10 vs. 28±10, P=0.027). No differences were found in the main MRI parameters.

AB - A polymorphism (PM) in the microsatellite of the promoter region of matrix metalloproteinase 9 (MMP-9), modulating its expression, could play a role in susceptibility to multiple sclerosis (MS). MMP-9 PM was determined in 95 patients with MS (MS Group) and 95 age- and sex-matched controls (Control Group). Comparison of allelic frequencies showed that a higher number of CA repeats characterized the MS group (P22 CA repeats (33±10 vs. 28±10, P=0.027). No differences were found in the main MRI parameters.

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KW - MRI

KW - Multiple sclerosis

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MMP-9 microsatellite polymorphism and multiple sclerosis

Abstract

Keywords

ASJC Scopus subject areas

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