MMSE and MoCA in Parkinson’s disease and dementia with Lewy bodies: a multicenter 1-year follow-up study

Roberta Biundo, L. Weis, S. Bostantjopoulou, E. Stefanova, C. Falup-Pecurariu, M. G. Kramberger, G. J. Geurtsen, A. Antonini, D. Weintraub, D. Aarsland

Research output: Contribution to journalArticle

Abstract

The Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) are the most commonly used scales to test cognitive impairment in Lewy body disease (LBD), but there is no consensus on which is best suited to assess cognition in clinical practice and most sensitive to cognitive decline. Retrospective cohort study of 265 LBD patients [Parkinson’s disease (PD) without dementia (PDnD, N = 197), PD with dementia (PDD, N = 40), and dementia with Lewy bodies (DLB, N = 28)] from an international consortium who completed both the MMSE and MoCA at baseline and 1-year follow-up (N = 153). Percentage of relative standard deviation (RSD%) at baseline was the measure of inter-individual variance, and estimation of change (Cohen’s d) over time was calculated. RSD% for the MoCA (21 %) was greater than for the MMSE (13 %) (p = 0.03) in the whole group. This difference was significant only in PDnD (11 vs. 5 %, p <0.01), but not in PDD (30 vs. 19 %, p = 0.37) or DLB (15 vs. 14 %, p = 0.78). In contrast, the 1-year estimation of change did not differ between the two tests in any of the groups (Cohen’s effect

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalJournal of Neural Transmission
DOIs
Publication statusAccepted/In press - Feb 6 2016

Keywords

  • Dementia with Lewy bodies
  • MMSE
  • MoCA
  • Parkinson disease
  • Rate of cognitive decline

ASJC Scopus subject areas

  • Biological Psychiatry
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

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    Biundo, R., Weis, L., Bostantjopoulou, S., Stefanova, E., Falup-Pecurariu, C., Kramberger, M. G., Geurtsen, G. J., Antonini, A., Weintraub, D., & Aarsland, D. (Accepted/In press). MMSE and MoCA in Parkinson’s disease and dementia with Lewy bodies: a multicenter 1-year follow-up study. Journal of Neural Transmission, 1-8. https://doi.org/10.1007/s00702-016-1517-6