Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function

Antonio Maria Leone, Sergio Rutella, Giuseppina Bonanno, Antonio Abbate, Antonio G. Rebuzzi, Silvia Giovannini, Mariaelena Lombardi, Leonarda Galiuto, Giovanna Liuzzo, Felicita Andreotti, Gaetano A. Lanza, Anna Maria Contemi, Giuseppe Leone, Filippo Crea

Research output: Contribution to journalArticle

Abstract

Aims: Recent data suggest that the administration of bone marrow-derived stem cells (BMSC) might improve myocardial perfusion and left ventricular (LV) function after acute myocardial infarction (AMI). The aim of this study was to assess spontaneous mobilization of BMSC expressing the haematopoietic and endothelial progenitor cell-associated antigen CD34+ after AMI and its relation to post-infarction remodelling. Methods and results: Peripheral blood concentration of CD34+ BMSC was measured by flow cytometry in 54 patients with AMI, 26 patients with chronic stable angina (CSA), and 43 normal healthy subjects. In patients with AMI, LV function was measured by 2D-echocardiography. Eighteen AMI patients were reassessed at 1 year. BMSC concentration was higher in patients with AMI (mean peak value: 7.04 ± 6.27 cells/μL), than in patients with CSA (3.80 ± 2.12 cells/μL, P = 0.036) and in healthy controls (1.87 ± 1.52 cells/μL, P <0.001). At multivariable analysis statin use (P <0.001), primary percutaneous intervention (P = 0.048) and anterior AMI (P = 0.05) were the only independent predictors of increased BMSC mobilization after AMI. In the 28 patients without subsequent acute coronary events reassessed at 1 year follow-up, CD34+ cell concentration was an independent predictor of global and regional improvement of LV function (r = 0.52, P = 0.004 and r = -0.41, P = 0.03, respectively). Conclusion: AMI is followed by enhanced spontaneous mobilization of BMSC, in particular, in patients on statin therapy and following a primary percutaneous intervention. More importantly persistent spontaneous mobilization of BMSC might contribute to determine a more favourable post-AMI remodelling.

Original languageEnglish
Pages (from-to)1196-1204
Number of pages9
JournalEuropean Heart Journal
Volume26
Issue number12
DOIs
Publication statusPublished - Jun 2005

Keywords

  • Myocardial infarction
  • Remodelling
  • Stem cells

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Leone, A. M., Rutella, S., Bonanno, G., Abbate, A., Rebuzzi, A. G., Giovannini, S., Lombardi, M., Galiuto, L., Liuzzo, G., Andreotti, F., Lanza, G. A., Contemi, A. M., Leone, G., & Crea, F. (2005). Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function. European Heart Journal, 26(12), 1196-1204. https://doi.org/10.1093/eurheartj/ehi164